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In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.<\/jats:p>","DOI":"10.1177\/08853282241237323","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T15:49:06Z","timestamp":1709308146000},"page":"989-999","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy"],"prefix":"10.1177","volume":"38","author":[{"given":"Chao","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China"},{"name":"International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou, 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