{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:48:49Z","timestamp":1789192129129,"version":"build-2803163510"},"reference-count":85,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sharif University ofTechnology"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Since conventional antibiotics are almost ineffective on methicillin-resistant Staphylococcus aureus (MRSA) strains, designing their antibacterial alternatives is necessary. Besides, the use of vancomycin is applied for specific detection of the bacteria. Silver-incorporated vancomycin-modified mesoporous silica nanoparticles (MSNs@Van@Ag NPs) were designed for detection and treatment of MRSA bacteria. Mesoporous silica nanoparticles (MSNs) were synthesized through the template method, modified with vancomycin, and finally incorporated with silver nanoparticles (Ag NPs). The MSNs@Van@Ag NPs with a homogenously spherical shape, average size of 50-100\u00a0nm, surface area of 955.8\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    \/g, and thermal stability up to 200\u00b0C were successfully characterized. The amount of Ag incorporated into the MSNs@Van@Ag was calculated at 3.9\u00a0ppm and the release amount of Ag was received at 2.92\u00a0ppm (75%) after 100\u00a0h. The in vitro antibacterial susceptibility test showed the MIC of 100\u00a0\u03bcg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for MSNs@Van and 50\u00a0\u03bcg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for MSNs@Van@Ag, showing in vitro enhanced effect of Ag and vancomycin in the bactericidal process. An in vivo acute pneumonia model was performed and biochemical assays and pathological studies confirmed the nanomedicine\u2019s short-term safety for in vivo application. Cytokine assay using ELISA showed that MSN@Van@Ag causes a reduction of pro-inflammatory cytokines and bacterial proliferation leading to alleviation of inflammatory response.\n                  <\/jats:p>","DOI":"10.1177\/08853282241274517","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T04:46:35Z","timestamp":1724820395000},"page":"439-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Antibacterial activity of a silver-incorporated vancomycin-modified mesoporous silica against methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1177","volume":"39","author":[{"given":"Mehdi","family":"Chamani","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 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