{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:47:51Z","timestamp":1789238871728,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Postgraduate Research& Practice Innovation Program of Jiangsu Province, and the Jiangsu Province Key Laboratory of Materials Surface Science and Technology","award":["KFBM20230005"],"award-info":[{"award-number":["KFBM20230005"]}]},{"name":"Changzhou Science and Technology Project Fund","award":["CQ20214029"],"award-info":[{"award-number":["CQ20214029"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>The 3D printing of porous titanium scaffolds reduces the elastic modulus of titanium alloys and promotes osteogenic integration. However, due to the biological inertness of titanium alloy materials, the implant-bone tissue interface is weakly bonded. A calcium silicate (CS) coating doped with polymetallic ions can impart various biological properties to titanium alloy materials. In this study, CuO and SrO binary-doped CS coatings were prepared on the surface of 3D-printed porous titanium alloy scaffolds using atmospheric plasma spraying and characterized by SEM, EDS, and XRD. Both CuO and SrO were successfully incorporated into the CS coating. The in vivo osseointegration evaluation of the composite coating-modified 3D-printed porous titanium alloy scaffolds was conducted using a rabbit bone defect model, showing that the in vivo osseointegration of 2% CuO-10% SrO-CS-modified 3D-printed porous titanium alloy was improved. The in vitro antimicrobial properties of the 2% CuO-10% SrO-CS-modified 3D-printed porous titanium alloy were evaluated through bacterial platform coating, co-culture liquid absorbance detection, and crystal violet staining experiments, demonstrating that the composite coating exhibited good antimicrobial properties. In conclusion, the composite scaffold possesses both osteointegration-promoting and antimicrobial properties, indicating a broad potential for clinical applications.<\/jats:p>","DOI":"10.1177\/08853282241287916","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T13:55:29Z","timestamp":1727358929000},"page":"607-619","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced osseointegration and antimicrobial properties of 3D-Printed porous titanium alloys with copper-strontium doped calcium silicate coatings"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1414-0993","authenticated-orcid":false,"given":"Xin qi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Affiliated Changzhou Second People\u2019s Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Affiliated Changzhou Second People\u2019s Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long hui","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Fifth People\u2019s Hospital of Ningxia, Shizuishan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua qiao","family":"Shen","sequence":"additional","affiliation":[{"name":"Graduate School, Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Affiliated Changzhou Second People\u2019s Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"bibr1-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-011-0585-5"},{"key":"bibr2-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.06.004"},{"key":"bibr3-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3390\/polym12091863"},{"key":"bibr4-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.12.002"},{"key":"bibr5-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12353"},{"key":"bibr6-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00662"},{"key":"bibr7-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2016.05.013"},{"key":"bibr8-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2018.04.010"},{"key":"bibr9-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.064"},{"key":"bibr10-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30073"},{"key":"bibr11-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30582"},{"key":"bibr12-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0859-0"},{"key":"bibr13-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.08.006"},{"key":"bibr14-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00080-4"},{"key":"bibr15-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00305.x"},{"key":"bibr16-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00692-15"},{"key":"bibr17-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.11.016"},{"key":"bibr18-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb21522a"},{"key":"bibr19-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.07.062"},{"key":"bibr20-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2010.09.011"},{"key":"bibr21-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1115\/1.4040158"},{"key":"bibr22-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-018-0080-5"},{"key":"bibr23-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420965797"},{"key":"bibr24-08853282241287916","first-page":"4441","volume":"25","author":"WangQ WYP","year":"2021","journal-title":"China Tissue Eng Res"},{"key":"bibr25-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c16459"},{"key":"bibr26-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1177\/0885328220942906"},{"key":"bibr27-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2005.07.007"},{"key":"bibr28-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-020-00352-4"},{"key":"bibr29-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3390\/ma14226901"},{"key":"bibr30-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1515\/rams-2023-0148"},{"key":"bibr31-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.591467"},{"key":"bibr32-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109833"},{"key":"bibr33-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.928799"},{"key":"bibr34-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.02.053"},{"key":"bibr35-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.04.030"},{"key":"bibr36-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3390\/ma14082030"},{"key":"bibr37-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc2302028"},{"key":"bibr38-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050673"},{"key":"bibr39-08853282241287916","doi-asserted-by":"publisher","DOI":"10.3390\/coatings10090828"},{"key":"bibr40-08853282241287916","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr08375d"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282241287916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282241287916","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282241287916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:52:48Z","timestamp":1777492368000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282241287916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/08853282241287916"],"URL":"https:\/\/doi.org\/10.1177\/08853282241287916","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]}}}