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Only 20% to 30% of patients can be treated with potentially curative surgical resection. Local therapies such as radioembolization and hepatic arterial perfusion may be a more effective treatment strategy. The active ingredients of natural plants have aroused wide interest in the treatment of tumors. Triptolide shows toxic effects on a variety of epithelioid carcinoma cells. However, there is currently a lack of suitable delivery system for the treatment of ICC. In this study, organometallic framework material ZIF-8 was chosen to load TP, and then encapsuled in HSA micro-nanoparticles for the perfusion treatment of ICC. The results of SEM, XRD, and FTIR showed that ZIF-8 nanoparticles were encapsuled in HSA micro-nanoparticles. ZIF-8 nanoparticles (57.89 \u00b1 12.24%) and TP@ZIF-8\/HSA (36.8 \u00b1 4.71%) micro-nanoparticles could significantly inhibited proliferation of RBE cell. Also, TP@ZIF-8\/HSA micro-nanoparticles of all groups exhibited favorable cytocompatibility to L929 cells and hemocompatibility. RT-qPCR and western blot showed that ZIF-8 and TP induced apoptosis in cancer cells through mitochondria-related pathways. The results demonstrated that TP@ZIF-8\/HSA was a potential chemotherapy candidate for the treatment of ICC.<\/jats:p>","DOI":"10.1177\/08853282251318872","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:08:07Z","timestamp":1738228087000},"page":"1030-1036","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Human serum albumin microspheres synchronously loaded with ZIF-8 and triptolide (TP) for the treatment of intrahepatic cholangiocarcinoma"],"prefix":"10.1177","volume":"39","author":[{"given":"Fuxin","family":"Li","sequence":"first","affiliation":[{"name":"The people\u2019s hospital of Hezhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"The people\u2019s hospital of Hezhou, Guangxi, 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