{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:37:19Z","timestamp":1783838239933,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key Scientific Research Project of Wannan Medical College","award":["No. WK2020ZF15"],"award-info":[{"award-number":["No. WK2020ZF15"]}]},{"name":"General Scientific Research Project of Wuhu Municipal Health Commission","award":["No. WHWJ2023y001"],"award-info":[{"award-number":["No. WHWJ2023y001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Blockage of the interaction between programmed death receptor-1 (PD-1) and programmed death ligand-1 (PD-L1) can restore T-cell activity and enhance antitumor immunity. PD-1\/PD-L1 pathway inhibitors have promising applications in the treatment of advanced prostate cancer (PCa). We successfully developed a peptides-functionalized gold nanoconstruct (P-AuNS) consisted of PD-L1-binding peptide (PD-L1pep, P) and gold nanostar (AuNS), which could bind to cell-surface PD-L1 specifically and deliver PD-L1 into PCa cells with high efficiency. In PCa cells, P-AuNS can efficiently degrade PD-L1 in a lysosomal-dependent manner. In the co-culture system of Jurkat cells and DU145 cells, P-AuNS restored the proliferative capacity and interferon-gamma (IFN-\u03b3) secretion level of Jurkat cells inhibited by co-cultured DU145 cells, indicating that P-AuNS effectively hampered the interaction between PD-1 and PD-L1. In addition, in PCa-bearing mice, P-AuNS can effectively inhibit tumor growth and down-regulate PD-L1 protein levels, and in vivo experimental results show that P-AuNS has no systemic toxicity. P-AuNS block the interaction between PD-1 and PD-L1 by efficiently degrading PD-L1, thus restoring the antitumor activity of T cells and inhibiting tumor progression of PCa. In all, P-AuNS has great promise as a potential immunotherapy strategy in the treatment of advanced PCa and even other solid tumors.<\/jats:p>","DOI":"10.1177\/08853282251319473","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:24:56Z","timestamp":1740410696000},"page":"1188-1201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Peptides-functionalized gold nanostars enhanced degradation of PD-L1 for improved prostate cancer immunotherapy"],"prefix":"10.1177","volume":"39","author":[{"given":"Liangjun","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9219-9388","authenticated-orcid":false,"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00243-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2018.1464388"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy232"},{"key":"e_1_3_3_7_2","first-page":"727","article-title":"PD-1\/PD-L1 pathway: current researches in cancer","volume":"10","author":"Han Y","year":"2020","unstructured":"Han Y, Liu D, Li L. PD-1\/PD-L1 pathway: current researches in cancer. Am J Cancer Res 2020; 10: 727\u2013742.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00561"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-015-0396-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2703"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-15-2042"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15817"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21596"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.020"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.011"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0392-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23997-x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051131"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.12.036"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn4033294"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.051"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450121666200609142219"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119984"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700596"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002031"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00810"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn5070953"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.102144"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05138"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.6630"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7235"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1jm10603a"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0057"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2020.2928"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.11632"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251319473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282251319473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251319473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:52:54Z","timestamp":1777492374000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282251319473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/08853282251319473"],"URL":"https:\/\/doi.org\/10.1177\/08853282251319473","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]}}}