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This study aimed to evaluate the therapeutic effects of Haematococcus carbon dots (HP-CDs) on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. HP-CDs were synthesized from Haematococcus pluvialis (HP) using a hydrothermal method involving Rhodococcus amphitrite. The effects of HP-CDs on DSS-induced ulcerative colitis in mice were evaluated through histological and pathological analyses. Results demonstrated that HP-CDs significantly alleviated colitis, reducing body weight loss, Disease Activity Index (DAI) scores, and colonic atrophy. Moreover, HP-CDs suppressed MPO activity and decreased the expression of pro-inflammatory cytokines, including TNF-\u03b1, IL-1\u03b2, and IL-6, in colonic tissues. 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