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An\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    gel is recommended as a remedy, as it can be converted into a gel upon contact with the eye and adhere for an extended period. Tamarind seed polysaccharide (TSP) is non thermo-sensitive and possesses the necessary properties to be used as a vehicle for administering medication to the eye. However, the administration of medication into the eyes through TSP based\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    gel has not yet been studied.\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -isopropyl acrylamide was grafted onto TSP to make it temperature sensitive. Then, a TSP-based thermo-sensitive\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    gel-forming solution loaded with dorzolamide hydrochloride (2% w\/v) was developed and evaluated through\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    tests. The\n                    <jats:italic toggle=\"yes\">in situ gel<\/jats:italic>\n                    forming solution turns into a gel at 37\u00b0C. The safety and efficacy of the formulation were confirmed through an\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    study on rabbit eyes with induced glaucoma. The findings indicate that the\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    gel significantly reduced intraocular pressure (IOP), with effects comparable to those of marketed eye drops.\n                  <\/jats:p>","DOI":"10.1177\/08853282251369232","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T19:50:27Z","timestamp":1755028227000},"page":"650-665","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In vitro<\/i>\n                    ,\n                    <i>ex vivo<\/i>\n                    , and\n                    <i>in vivo<\/i>\n                    evaluation of polysaccharide based thermo-sensitive\n                    <i>in situ<\/i>\n                    gel for the treatment of glaucoma"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1271-9309","authenticated-orcid":false,"given":"Sonali","family":"Mandal","sequence":"first","affiliation":[{"name":"Jadavpur University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-6523","authenticated-orcid":false,"given":"Nihar Ranjan","family":"Das","sequence":"additional","affiliation":[{"name":"Roland Institute of Pharmaceutical Sciences"},{"name":"GITAM Deemed to Be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3490-8707","authenticated-orcid":false,"given":"Kaushik","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Jadavpur University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-2548","authenticated-orcid":false,"given":"Tapan Kumar","family":"Giri","sequence":"additional","affiliation":[{"name":"Jadavpur University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119264"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.10.029"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.07.085"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121847"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-8453.59512"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3396-3401.2004"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ02767G"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-7-5"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030673"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12010022"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/gels8070454"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/gels8110723"},{"key":"e_1_3_6_14_2","first-page":"273","article-title":"Temperature and pH dependent solubility of novel poly (N-isopropylacrylamide) copolymers","volume":"201","author":"Kuckling D","year":"2000","unstructured":"Kuckling D, Adler HJ, Arnd KF, et al. 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