{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:03:19Z","timestamp":1777788199636,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    A common and fatal consequence of diabetes, diabetic foot ulcers (DFU) are linked to an increased risk of mortality and amputation. The current study aimed to develop and evaluate a polyherbal gel formulation (PGF) employing hydro-alcoholic extracts of\n                    <jats:italic toggle=\"yes\">Solanum nigrum<\/jats:italic>\n                    (fruits),\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    (leaves),\n                    <jats:italic toggle=\"yes\">Psidium guajava<\/jats:italic>\n                    (fruits), and\n                    <jats:italic toggle=\"yes\">Moringa oleifera<\/jats:italic>\n                    (bark) at different concentrations for the efficient treatment and management of DFU. The anti-oxidant, anti-diabetic, anti-inflammatory, anti-bacterial, and wound healing activities of PGFs were investigated using a range of cell-based\n                    <jats:italic toggle=\"yes\">in-vitro<\/jats:italic>\n                    assays and animal models. Each PGF exhibited a remarkable \u03b1-amylase inhibitory activity, with PGF 4 demonstrating the highest inhibition of \u03b1-amylase (IC50- 0.093\u00a0mg\/mL). Fluorescent microscopy analysis revealed significant glucose uptake by McCoy fibroblast cells in the presence of PGFs. In addition to this, the PGFs exhibited notable anti-bacterial efficacy against a spectrum of tested pathogens. The administration of PGFs to McCoy cells displayed enhanced wound closure, with 86.04 % closure rate in presence of PGF 4 in scratch assay.\n                    <jats:italic toggle=\"yes\">In-vivo<\/jats:italic>\n                    assessments encompassed the evaluation of PGFs efficacy in inducing caudal fin regeneration in Zebra fish, revealing PGF 3 and PGF 4 to be effective with a substantial 56.67% and 73.3% regeneration, respectively, after 8 days post-amputation. In a diabetic rat model, wherein circular wounds were inflicted, a 14\u00a0days regimen of topical PGF 4 application demonstrated enhanced efficacy compared to the standard Calendula cream (79%) in expediting diabetic wound closure. Collectively, these findings underscore the promising potential of PGF 4 for advance therapeutic approach in the management of DFUs.\n                  <\/jats:p>","DOI":"10.1177\/08853282251374422","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T23:48:06Z","timestamp":1756424886000},"page":"899-915","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyherbal gel formulation with\n                    <i>Solanum nigrum<\/i>\n                    ,\n                    <i>Aloe vera, Psidium guajava<\/i>\n                    and\n                    <i>Moringa oleifera<\/i>\n                    : A preclinical evaluation for accelerated wound healing in diabetic foot ulcers"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7965-2621","authenticated-orcid":false,"given":"Diksha","family":"Manhas","sequence":"first","affiliation":[{"name":"Jaypee University of Information Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-1070","authenticated-orcid":false,"given":"Udayabanu","family":"Malairaman","sequence":"additional","affiliation":[{"name":"Jaypee University of Information Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-0970-z"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-8-5"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225470.42514.8f"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1142\/S2339547820300024"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.103330"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0073"},{"key":"e_1_3_6_10_2","doi-asserted-by":"crossref","unstructured":"Rajini PS Muralidhara M. 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