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In this study, we proposed to prepare a novel epithelial cell adhesion molecule (EpCAM)\/Vimentin dual-targeting modified polyester albumin nanocarriers to load LEN (EpCAM\/Vimentin-LEN-ANs) to improve the therapeutic efficacy of the drug for HCC. The results showed that the EpCAM\/Vimentin-LEN-ANs had a particle size of (236.08 \u00b1 6.39) nm, a potential of (38.93 \u00b1 7.15) mv, and were characterized by nanovesicles, with an encapsulation rate of (97.57 \u00b1 2.43) % and a drug loading capacity of (11.16 \u00b1 1.75) %. EpCAM\/Vimentin-LEN-ANs can specifically target HCC cells and slowly release LEN drugs, thus effectively inhibiting the growth of HCC cells; in addition, they have good anti-tumor effects and biosafety in vivo. In this study, EpCAM\/Vimentin-LEN-ANs were successfully prepared, which can carry LEN and then target into HCC cells to achieve precise delivery and release of drugs, improve anti-tumor efficacy and alleviate the toxic side effects of anti-tumor drugs on the organism, which has a better potential for application and clinical translation in the treatment of HCC.<\/jats:p>","DOI":"10.1177\/08853282251374426","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:29:46Z","timestamp":1756891786000},"page":"743-754","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel dual-targeted modified polyester albumin nano-carriers enhance the efficacy of hepatocellular carcinoma outcomes after encapsulating lenvatinib"],"prefix":"10.1177","volume":"40","author":[{"given":"Yong","family":"Jiang","sequence":"first","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Fan","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Chai","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xiao","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhu","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6347-222X","authenticated-orcid":false,"given":"Bin","family":"Yi","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1453709"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071422"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v15.i4.544"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1134\/S263516762460086X"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luae121"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.979519"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-21-0053"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000237"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01647-1"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1874"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-023-00244-0"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300105"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01659-x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00469K"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202103524"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR06349F"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-024-00743-w"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma17143544"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.104050"},{"issue":"3","key":"e_1_3_5_22_2","first-page":"231","article-title":"Investigating non-covalent interactions of human serum albumin with doxorubicin and folic acid","volume":"18","author":"Bauer IA","year":"2024","unstructured":"Bauer IA, Dmitrienko EV. 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