{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:03:26Z","timestamp":1777788206666,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Anhui Province Clinical Medical Research and Transformation Special Project","award":["202304295107020071"],"award-info":[{"award-number":["202304295107020071"]}]},{"name":"The Health and Wellness Research Projects in Suzhou City","award":["SZWJ2023a037"],"award-info":[{"award-number":["SZWJ2023a037"]}]},{"name":"The Wu Jieping Medical Foundation Clinical Research Special Funding Project","award":["320.6750.2022-19-9"],"award-info":[{"award-number":["320.6750.2022-19-9"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    A single drug therapeutic approach fails to sufficiently eliminate tumors in clinics, owing to the tumoral complexity and heterogeneity. The integration of chemotherapy with novel treatment modalities offers a promising synergistic strategy for enhancing therapeutic outcomes. Herein, we successfully develop pH-triggered dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy, which are prepared through incorporation of Cu\n                    <jats:sub>2-x<\/jats:sub>\n                    Se nanoparticles (NPs) and lipophilic mixture (OPC) including orthoester compound, polycaprolactone and carboplatin into imine-crosslinked polysaccharide-based hydrogels. The dynamic imine linkages endow the hydrogels with favorable injectability and self-adaptability as well as tumoral extracellular pH-triggered degradation. OPC can enhance drug escape from hydrogels, tumor penetration and pH-responsive prolonged and sustained release of the drug. Cu\n                    <jats:sub>2-x<\/jats:sub>\n                    Se NPs endow the hydrogels with photothermal therapy (PTT), photodynamic therapy (PDT) and chemo-dynamic therapy (CDT). These superior physicochemical properties result in significant tumor growth inhibition while decreasing side effect on normal tissues. Therefore, the pH-responsive dynamic organic nanocomposite hydrogels have great potential for local tumor therapy in clinics.\n                  <\/jats:p>","DOI":"10.1177\/08853282251381646","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:13:30Z","timestamp":1758845610000},"page":"854-865","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["pH-responsive dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3427-089X","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiqing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010183"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266258838231020102401"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c02914"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01714"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c05645"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142372"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155023"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC01136D"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122645"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004213"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S182475"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.02.012"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403296"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR02884F"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00492"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114244"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102518"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-024-06576-x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302054"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102493"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129529"},{"key":"e_1_3_4_23_2","first-page":"e02349","article-title":"Injectable ROS\/pH-Responsive hydrogel for synergistic chemo-photodynamic tumor therapy and enhanced wound healing","author":"Yi DY","year":"2025","unstructured":"Yi DY, Wang T, Xu SS, et al. 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