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This study addressed infection control and bone regeneration simultaneously using hydroxyapatite and natural biopolymers. Moxifloxacin hydrochloride was delivered via composite scaffolds produced from polyvinyl alcohol\/gelatin and hydroxyapatite with potential applications in osteomyelitis treatment and bone tissue engineering. The composite scaffolds exhibited a well-defined porous architecture, characterised by macropores (\u2265100\u00a0\u00b5m) and micropores (\u226420\u00a0\u00b5m), facilitating cellular infiltration and drug loading. Biomineralization and cell culture assays were used to evaluate the scaffold\u2019s bioactivity and biocompatibility. Analyses of mineralized scaffolds using Fourier-transform infrared spectroscopy and scanning electron microscopy revealed HA nucleation on the scaffold\u2019s surface after immersion in simulated bodily fluid for varied time points. Protein adsorption and haemolysis tests were conducted to confirm the blood compatibility of scaffolds. Cell culture studies using human mesenchymal stem cells indicated non-cytotoxicity and robust cell adhesion. 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