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Therefore, developing a functional material with bone tissue regeneration capabilities has significant practical importance. In this study, Zn doped silica nanoparticles were produced by microemulsion assisted sol-gel method and then different concentrations of nanoparticles was added to the gelatin methacrylated hydrogel to form the composite materials for potential rat mandibular bone defect repair. First, the elements of Zn, O, and Si were effectively integrated into nanoparticles. SEM analysis revealed the presence of Zn doped silica nanoparticles on the hydrogel\u2019s surface. Second, the 0.2 ZnSNPs\/GelMA had good biocompatibility, and the ability to effectively induce osteogenic differentiation in Bone marrow mesenchymal stem cells (BMSCs). Finally, in vivo 4\u00a0mm diameter circular bone defect repair experiments indicated that the 0.2 ZnSNPs\/GelMA promoted new bone regeneration in vivo. Overall, we believe that composite material with good biocompatibility and excellent osteoinductive property will provide new ideas for enhancing the efficacy of hard tissue repair.<\/jats:p>","DOI":"10.1177\/08853282251383321","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:39:22Z","timestamp":1758908362000},"page":"887-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Zinc doped silica nanoparticles gelatin methacrylate hydrogel on BMSCs cell viability and differentiation: Potential for rat mandibular bone defect repair"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2117-1155","authenticated-orcid":false,"given":"Hai","family":"Liu","sequence":"first","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6427-0285","authenticated-orcid":false,"given":"Yuteng","family":"Chen","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-3247","authenticated-orcid":false,"given":"Yifan","family":"Ma","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Qiang","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0472-1533","authenticated-orcid":false,"given":"Donglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wannan Medical College"},{"name":"Wuhu City Oral Tissue Repair and Regeneration Technology Research and Development Center"},{"name":"Wannan Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S270681"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34967"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00095"},{"key":"e_1_3_3_5_2","first-page":"101515","article-title":"Osteogenic potential of dental and oral derived stem cells in bone tissue engineering among animal models: an update","volume":"71","author":"Berberi A","year":"2021","unstructured":"Berberi A, Fayyad-Kazan M, Ayoub S, et al. 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