{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:18:57Z","timestamp":1791307137723,"version":"4.3.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002945","name":"Direccion de Investigacion, Universidad Nacional de Colombia","doi-asserted-by":"publisher","award":["57521"],"award-info":[{"award-number":["57521"]}],"id":[{"id":"10.13039\/501100002945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>In this study, we explored the design of polymeric nanocapsules as vehicles for controlled release of iron. Amphiphilic block copolymers (ABCs) composed of polyethylene glycol (PEG) and poly (\u03b5-caprolactone) (PCL) segments were synthesized via ring-opening polymerization (ROP), using PEG and methoxy-PEG (mPEG) with varying molecular weights as macroinitiators. Structural and molecular characterizations using infrared spectroscopy, proton nuclear magnetic resonance and gel permeation chromatography confirmed successful copolymerization and narrow dispersity indices (\u00d0 &lt;1.5). Iron-loaded nanocapsules were formulated using the double emulsion solvent evaporation (DESE) technique with synthesized PEG-b-PCL copolymers as polymeric precursors. The impact of the copolymer composition on the particle size, morphology, and encapsulation efficiency (EE%) was evaluated. Spherical nanocapsules with diameters below 500\u00a0nm were obtained, and a positive correlation was observed between copolymer molecular weight and EE%, with the highest value (74.4%) achieved for the Fe@COP5-96 formulation. Differential scanning calorimetry (DSC) analysis revealed that iron incorporation altered the thermal behavior of the copolymers, resulting in a shift of the melting peaks toward lower temperatures and a decrease in melting enthalpy, consistent with reduced crystallinity arising from ion\u2013polymer interactions. The iron release kinetics exhibited a sustained release behavior. These results demonstrate the potential of PEG-b-PCL nanocapsules as effective carriers for ionic species with promising applications in nutrient delivery and medical therapies.<\/jats:p>","DOI":"10.1177\/08853282251393482","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:55:58Z","timestamp":1761911758000},"page":"1263-1273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Double emulsion-based encapsulation of iron in amphiphilic block copolymer nanocarriers for controlled release"],"prefix":"10.1177","volume":"40","author":[{"given":"Valentina","family":"Camacho","sequence":"first","affiliation":[{"name":"Universidad Nacional de Colombia-Sede Bogot\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia-Sede Bogot\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7473-7855","authenticated-orcid":false,"given":"Leon","family":"Perez","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia-Sede Bogot\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.08.038"},{"issue":"1","key":"e_1_3_4_3_2","first-page":"226","article-title":"A study on the of nutrition, health and hygiene counselling impact on iron deficiency anaemia","volume":"21","author":"Gayen K","year":"2024","unstructured":"Gayen K, Kumar K, Rawat V. 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