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Nanomaterials are being used to improve the corneal scaffolds\u2019 mechanical strength, permeability, and transparency, as well as to enable the therapeutic agents\u2019 targeted delivery by nanocarriers. These improvements deal with important problems in corneal repair, like inflammation, infections, and neovascularization. While corneal transplantation remains a standard treatment, the risk of rejection and availability of donor tissue are the main limitations. Recent improvements in electrospinning have made it possible to make nanofibers that look like the natural extracellular matrix (ECM). These fibers have a large surface area and high porosity, which help cells grow, stick to each other, and change into different types of cells. Both synthetic and natural polymers have been successfully employed to fabricate biocompatible and biodegradable nanofibers, indicating their potential for the treatment of various corneal disorders. 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