{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:46:30Z","timestamp":1791009990058,"version":"4.1.0"},"reference-count":75,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Iron oxide nanoparticles (FeONPs) have promising biomedical applications but are limited by potential cytotoxic and genotoxic risks. This study addresses these concerns by synthesizing mycosynthesized FeONPs (M.FeONPs) having angiogenic properties using\n                    <jats:italic toggle=\"yes\">Apiospora aurea<\/jats:italic>\n                    , a mangrove-derived fungus, to enhance biocompatibility and reduce toxicity. The results showed that chemically synthesized FeONPs induced oxidative stress, cell cycle arrest, and apoptosis, whereas M.FeONPs exhibited lower toxicity and better compatibility in CHO-K1 cells. In vitro, genotoxicity assessments further revealed that FeONPs caused significant chromosomal aberrations and DNA damage, while M.FeONPs had reduced genotoxic effects. In vivo studies using Swiss albino mice confirmed that M.FeONPs induced minimal systemic toxicity, maintaining stable hematological and biochemical profiles, unlike FeONPs, which triggered immune stress and mild organ inflammation. In vivo, genotoxicity studies also demonstrated that M.FeONPs caused lesser clastogenic, mitotic, aneugenic, and teratogenic effects than chemically synthesized FeONPs. Hence, these findings confirm the potential of M.FeONPs for biomedical applications, particularly in reproductive health and therapeutics applications.\n                  <\/jats:p>","DOI":"10.1177\/08853282251393788","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:52:35Z","timestamp":1761864755000},"page":"1198-1217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mycosynthesised iron oxide nanoparticles using\n                    <i>Apiospora aurea<\/i>\n                    : Mitigating somatic and germline toxicity for safer biomedical applications"],"prefix":"10.1177","volume":"40","author":[{"given":"Asha Priya","family":"Mandarada","sequence":"first","affiliation":[{"name":"CSIR-Indian Institute of Chemical Technology (CSIR-IICT)"},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamshi Krishna","family":"Eruva","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Chemical Technology (CSIR-IICT)"},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhila","family":"Yaladanda","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Chemical Technology (CSIR-IICT)"},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Misra","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Chemical Technology (CSIR-IICT)"},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-3905","authenticated-orcid":false,"given":"Srinivasa Rao","family":"Mutheneni","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Chemical Technology (CSIR-IICT)"},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01237-y"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02235-0"},{"key":"e_1_3_7_4_2","first-page":"2","article-title":"Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers","volume":"3445","author":"Wahajuddin A","year":"2012","unstructured":"Wahajuddin A. Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine 2012; 3445: 2.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17165817"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41204-020-00076-y"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1385272823666190314153208"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c00673"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2020.1731896"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano7100307"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2024.2399039"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1515\/bnm-2013-0007"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00271C"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092327"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3NA00071K"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA11079J"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092327"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.05.006"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2006.18.2.182"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912629107"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.12.068"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/17518253.2017.1339831"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2023.106982"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105502"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103703"},{"key":"e_1_3_7_26_2","volume-title":"Test No. 474: mammalian erythrocyte micronucleus test, OECD guidelines for the testing of chemicals, section 4","author":"OECD","year":"2016","unstructured":"OECD. Test No. 474: mammalian erythrocyte micronucleus test, OECD guidelines for the testing of chemicals, section 4. OECD Publishing, 2016."},{"key":"e_1_3_7_27_2","volume-title":"Guidance document on the recognition, assessment and use of clinical signs as humane endpoints for experimental animals used in safety evaluation, OECD Environment, Health and Safety Publications, Series on Testing and Assessment No. 19","author":"OECD","year":"2000","unstructured":"OECD (2000). Guidance document on the recognition, assessment and use of clinical signs as humane endpoints for experimental animals used in safety evaluation, OECD Environment, Health and Safety Publications, Series on Testing and Assessment No. 19. OECD Publishing."},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2012.08.007"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104592"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V24.3.267.267"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41021-016-0044-x"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.567"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.959"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1455205"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129818"},{"key":"e_1_3_7_36_2","first-page":"204","article-title":"Aneuploid epididymal sperm detected in chromosomally normal and Robertsonian translocation-bearing mice using a new three-chromosome FISH method","volume":"105","author":"Lowe X","year":"1996","unstructured":"Lowe X, O\u2019Hogan S, Moore D2nd, et al. Aneuploid epididymal sperm detected in chromosomally normal and Robertsonian translocation-bearing mice using a new three-chromosome FISH method. Chromosoma 1996; 105: 204\u2013210.","journal-title":"Chromosoma"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.11.4425"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00457"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.3402\/nano.v1i0.5358"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-9-229"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2019.11.026"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.06.005"},{"key":"e_1_3_7_43_2","article-title":"Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications","volume":"1761","author":"Chauhan S","year":"2012","unstructured":"Chauhan S, Yallapu M, Othman S, et al. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. Int J Nanomedicine 2012; 1761.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2017.1314036"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071811-150124"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03097"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.027"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/583438"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/cryst12081089"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127302"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16544-7"},{"key":"e_1_3_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.027"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319370011"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9972-0"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2010.2488"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185554"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1509171"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72041-8_12"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.21909"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-016-5157-0"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-018-2457-x"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx200513t"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.04.008"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15237H"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn305872d"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17838-0"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.09.20"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.08.044"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060043"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.12.031"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000763"},{"key":"e_1_3_7_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.08.027"},{"key":"e_1_3_7_73_2","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2016.1214764"},{"key":"e_1_3_7_74_2","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2021.1917597"},{"key":"e_1_3_7_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22871"},{"key":"e_1_3_7_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251393788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282251393788","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251393788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:53:11Z","timestamp":1777492391000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282251393788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/08853282251393788"],"URL":"https:\/\/doi.org\/10.1177\/08853282251393788","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}