{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:05Z","timestamp":1792804145451,"version":"4.5.0"},"reference-count":72,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00c0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013360","name":"Universidade do Extremo Sul Catarinense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013360","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars","award":["LR22A020002"],"award-info":[{"award-number":["LR22A020002"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ningbo Key R&D Program","award":["2022Z196"],"award-info":[{"award-number":["2022Z196"]}]},{"name":"Research Academy of Medicine Combining Sports, Ningbo","award":["2023001"],"award-info":[{"award-number":["2023001"]}],"id":[{"id":"https:\/\/ror.org\/00fnk0q46","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ningbo Leading Medical & Health Discipline","award":["2022-F15"],"award-info":[{"award-number":["2022-F15"]}]},{"name":"Ningbo Leading Medical & Health Discipline","award":["2022-F22"],"award-info":[{"award-number":["2022-F22"]}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"crossref","award":["2022J065"],"award-info":[{"award-number":["2022J065"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"crossref","award":["2022J120"],"award-info":[{"award-number":["2022J120"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ningbo Clinical Research center for Orthopedics and Exercise Rehabilitation","award":["2024L004"],"award-info":[{"award-number":["2024L004"]}]},{"name":"Zhejiang Rehabilitation Medical Association Scientific Research Special Fund","award":["ZKKY2023001"],"award-info":[{"award-number":["ZKKY2023001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Parkinson\u2019s disease is a progressive and irreversible neurodegenerative disease, whose main characteristic is the death of dopaminergic neurons. The animal model of Parkinsonism with reserpine has been used to mimic the consequences of Parkinson\u2019s disease. The use of gold nanoparticles in the treatment of several diseases arises due to their evidence of promising antioxidant and anti-inflammatory properties. Curcumin, in turn, presents neuroprotective activity in neurodegenerative diseases by reducing both inflammatory activity and oxidative stress in models of Parkinson\u2019s disease. This article seeks to understand the effects of the use of gold nanoparticles biosynthesized with curcumin in an experimental model of Parkinson\u2019s disease with reserpine. C57BL\/6 mice were used, divided into five groups: I. Control; II. Parkinson\u2019s disease; III. Parkinson\u2019s disease + Gold nanoparticles; IV. Parkinson\u2019s disease + Curcumin; V. Parkinson\u2019s disease + Gold nanoparticles biosynthesized with curcumin. Mice were subjected to subcutaneous induction with reserpine, and treatments began 24\u00a0h after administration. Seven treatments were applied at 24-h intervals via the intranasal route. After the last treatment, behavioral tests were conducted, followed by euthanasia and removal of brain structures. The combined treatments demonstrated potential neuroprotective effects, reversing inflammatory and oxidative processes and partially reversing Parkinsonian behavior. Together, these therapies potentiated their effects, leading to near-complete reversal of reserpine-induced damage.<\/jats:p>","DOI":"10.1177\/08853282251409687","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:37:26Z","timestamp":1766486246000},"page":"134-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Synergistic effects of biosynthesized gold nanoparticles with curcumin on motor, inflammatory, and oxidative parameters in a Parkinson\u2019s disease model"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-2257","authenticated-orcid":false,"given":"Paulo Cesar Lock","family":"Silveira","sequence":"first","affiliation":[{"name":"Ningbo University"},{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Milanez","family":"Venturini","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo de Bem","family":"Silveira","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Ramos","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"da Costa","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielli","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura de Roch","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"De Pieri","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Emilio","family":"Feuser","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Gu","sequence":"additional","affiliation":[{"name":"Ningbo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Andrez","family":"Machado-de-\u00c1vila","sequence":"additional","affiliation":[{"name":"Universidade do Extremo Sul Catarinense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Thirupathi","sequence":"additional","affiliation":[{"name":"Ningbo University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM2003ra020003"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00684-6"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02139-7"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.08.045"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S156347"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-019-00660-w"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440202003897"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.313040"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791110827"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113091"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00168-3"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111302"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.62347\/QHVI3317"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00107-0"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00605-7"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110539.ch5"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90326-2"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081574"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1482102"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/appliedchem4010006"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.04.027"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR00699C"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2020.100251"},{"issue":"2","key":"e_1_3_7_27_2","first-page":"e54671","article-title":"Gold nanoparticles in Parkinson\u2019s disease therapy: a focus on plant-based green synthesis","volume":"16","author":"Grancharova T","year":"2024","unstructured":"Grancharova T, Simeonova S, Pilicheva B, et al. Gold nanoparticles in Parkinson\u2019s disease therapy: a focus on plant-based green synthesis. Cureus 2024; 16(2): e54671.","journal-title":"Cureus"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220507022701"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115196"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.011"},{"issue":"7","key":"e_1_3_7_31_2","first-page":"e64846","article-title":"The evolving use of gold nanoparticles as a possible reversal agent for the symptoms of neurodegenerative diseases: a narrative review","volume":"16","author":"Kaye AD","year":"2024","unstructured":"Kaye AD, Sala KR, Dethloff D, et al. The evolving use of gold nanoparticles as a possible reversal agent for the symptoms of neurodegenerative diseases: a narrative review. Cureus 2024; 16(7): e64846.","journal-title":"Cureus"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01291788"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(02)00340-8"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90371-Y"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00164-6"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(87)90110-9"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12253"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.10.009"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9727-3"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4657"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051551"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101877"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042360"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.102.5.748"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(02)00344-5"},{"issue":"12","key":"e_1_3_7_46_2","first-page":"1454","article-title":"Bone marrow angiogenesis and its clinical correlates in myelofibrosis with myeloid metaplasia","volume":"89","author":"Arora B","year":"2004","unstructured":"Arora B, Ho CL, Hoyer JD, et al. Bone marrow angiogenesis and its clinical correlates in myelofibrosis with myeloid metaplasia. Haematologica 2004; 89(12): 1454\u20131458.","journal-title":"Haematologica"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00283"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01780-w"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60713-9"},{"issue":"70","key":"e_1_3_7_50_2","first-page":"9","article-title":"The discovery of dopamine deficiency in the Parkinsonian brain","author":"Hornykiewicz O","year":"2006","unstructured":"Hornykiewicz O. The discovery of dopamine deficiency in the Parkinsonian brain. J Neural Transm Suppl 2006; 70: 9\u201315.","journal-title":"J Neural Transm Suppl"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2017.19"},{"key":"e_1_3_7_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05378.x"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109768"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.256180"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1578"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500279"},{"issue":"12","key":"e_1_3_7_57_2","first-page":"1606","article-title":"Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons","volume":"25","author":"Zhu YG","year":"2004","unstructured":"Zhu YG, Chen XC, Chen ZZ, et al. Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons. Acta Pharmacol Sin 2004; 25(12): 1606\u20131612.","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-011-9249-8"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2003.9"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1823"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.10.004"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2019.05.008"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2017.01.003"},{"issue":"5","key":"e_1_3_7_64_2","first-page":"e25032","article-title":"An overview of Parkinson\u2019s disease: Curcumin as a possible alternative treatment","volume":"14","author":"Patel A","year":"2022","unstructured":"Patel A, Olang CA, Lewis G, et al. An overview of Parkinson\u2019s disease: Curcumin as a possible alternative treatment. Cureus 2022; 14(5): e25032.","journal-title":"Cureus"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001015"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0093-2"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2015.12.008"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.08.005"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1660"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524019666191016150757"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0329c.xd"},{"key":"e_1_3_7_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.06.005"},{"key":"e_1_3_7_73_2","doi-asserted-by":"publisher","unstructured":"Lal R Singh A Watts S Chopra K. Experimental models of Parkinson's disease: Challenges and Opportunities. Eur J Pharmacol. 2024 Oct 5;980:176819. doi: 10.1016\/j.ejphar.2024.176819. Epub 2024 Jul 18.","DOI":"10.1016\/j.ejphar.2024.176819"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251409687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282251409687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282251409687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:37:14Z","timestamp":1781066234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282251409687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/08853282251409687"],"URL":"https:\/\/doi.org\/10.1177\/08853282251409687","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}