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Recently, silver nanoparticles (AgNPs) have been investigated for their potential to promote wound healing; however, their application is limited by concerns over cytotoxicity and the development of bacterial resistance. To address these limitations, this study presents the development of a silver-alginate hydrogel (AgSACip) incorporating ciprofloxacin, synthesized using green tea extract act as a biogenic reducing and stabilizing agent. Sodium alginate, a naturally derived macromolecule, serves as a biocompatible matrix to stabilize AgNPs, reduce cytotoxicity, and enhance therapeutic efficacy. The wound healing potential of AgSACip was evaluated in diabetic and burn wound models, and its antibacterial activity, cytotoxic effects, and pharmacokinetics were analyzed using in silico methods. The results demonstrate that AgSACip significantly accelerates wound healing compared to AgNPs and ciprofloxacin alone, particularly in diabetic and burn wounds. Furthermore, AgSACip exhibited enhanced antibacterial activity against bacterial strains isolated from wound pus samples and showed no cytotoxicity toward NIH-3T3 fibroblast cells. These findings highlight the potential of AgSACip, a macromolecule-based hydrogel, as a safe and effective alternative to conventional wound dressings, offering improved wound healing outcomes.<\/jats:p>","DOI":"10.1177\/08853282261418176","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T19:26:42Z","timestamp":1768850802000},"page":"285-303","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Green-synthesized silver-alginate-ciprofloxacin hydrogel: A multifaceted therapeutic for enhanced diabetic and burn Wound healing"],"prefix":"10.1177","volume":"41","author":[{"given":"Kirti","family":"Singh","sequence":"first","affiliation":[{"name":"Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra Bahadur","family":"Yadav","sequence":"additional","affiliation":[{"name":"Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Rai","sequence":"additional","affiliation":[{"name":"Central University of Rajasthan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Nath","sequence":"additional","affiliation":[{"name":"Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchal","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti Suman","family":"Saxena","sequence":"additional","affiliation":[{"name":"Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-7935","authenticated-orcid":false,"given":"Ajay Vikram","family":"Singh","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"issue":"13","key":"e_1_3_5_2_2","first-page":"239","article-title":"Wounds - from physiology to wound dressing","volume":"105","author":"Kujath P","year":"2008","unstructured":"Kujath P, Michelsen A. 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