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We prepared polymeric nanoparticles (NPs) using N-acryloyl-L-tryptophan monomer by precipitation polymerization, and modified with polyethylene glycol and folate (PEG-FA) to improve the solubility and target folate-receptors (FR) overexpressed tumor tissues. Serving as drug carriers for vinblastine (VBL), NPs-PEG-FA with about 212.4\u00a0nm had the drug loading of VBL of 6.65 \u00b1 0.41% after co-incubating for 1 h and showed sustained-release in pH 7.4 PBS, in which 99.87 \u00b1 1.00% of VBL was released from NPs-PEG-FA during 72 h. Furthermore, NPs-PEG-FA was more efficiently taken up by FR positive Hela cells compared with NPs-PEG, which signified folate could enhance the internalization of NPs-PEG-FA into FR over-expressed cells. And NPs-PEG-FA began to enter Hela cells in large quantities from 3 h onwards, meanwhile the released drug increased more quickly in the first 3 h, which indicated most of the drugs would be released after entering tumor cells. 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NPs-PEG-FA could serve as drug carriers for delivering drugs into FR positive tumor cells.<\/jats:p>","DOI":"10.1177\/08853282261422124","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:03:12Z","timestamp":1774260192000},"page":"537-553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization and hemocompatibility of poly (N-acryloyl-L-tryptophan) nanoparticles as targeting delivery carriers for vinblastine"],"prefix":"10.1177","volume":"41","author":[{"given":"Zishan","family":"Zhou","sequence":"first","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Tao","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Duan","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Yu","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-8130","authenticated-orcid":false,"given":"Quanhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southern Medical University"},{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics"},{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma14226812"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-024-06199-6"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113006"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym16172547"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144625"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110605"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00564"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1900-1_9"},{"issue":"12","key":"e_1_3_7_10_2","first-page":"196","article-title":"Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty","volume":"8","author":"Zhao X","year":"2022","unstructured":"Zhao X, Li S, Du X, et al. 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