{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:25:16Z","timestamp":1789046716934,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Maxillofacial bone defects remain a complex clinical challenge due to their complex anatomy and limited regenerative capacity. In this study, a bioactive chitosan (CS) scaffold co-incorporated with nicotinamide mononucleotide (NMN) and naringin (Ng) was designed to stimulate osteogenesis and cellular metabolism for enhanced bone regeneration. Fourier-transform infrared analysis verified successful molecular integration of NMN and Ng within the chitosan framework, while scanning electron microscopy showed a uniformly porous surface favorable for stem-cell adhesion. Dental pulp stem cells (DPSCs) cultured on CS\/NMN\/Ng scaffolds exhibited enhanced cell proliferation, mitochondrial activity, and osteogenic differentiation compared with unmodified chitosan. At the cellular level, calcium deposition was markedly increased; molecular analysis confirmed up-regulated expression of Runx2, alkaline phosphatase (ALP), and type-I collagen. The bone regenerative capacity was further validated in a rat mandibular defect model, where micro-computed tomography and histological staining demonstrated near-complete closure of the defect with increased bone volume fraction and trabecular density after 8\u00a0weeks. Overall, the NMN\u2013naringin-functionalized chitosan scaffold provides a metabolically active, osteoinductive microenvironment that promotes bone regeneration, indicating a translational potential for maxillofacial and craniofacial bone tissue engineering applications.<\/jats:p>","DOI":"10.1177\/08853282261443995","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:33:32Z","timestamp":1776767612000},"page":"528-536","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive chitosaan\u2013nicotinamide mononucleotide\u2013naringin composite scaffolds for enhanced maxillofacial bone regeneration"],"prefix":"10.1177","volume":"41","author":[{"given":"Peiyao","family":"Chen","sequence":"first","affiliation":[{"name":"Wuxi Stomatological Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2311-3680","authenticated-orcid":false,"given":"Qixin","family":"Hao","sequence":"additional","affiliation":[{"name":"Wuxi Stomatological Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-07676-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213968"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.03.032"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109197"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/md21030147"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods13223572"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093716"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods12122327"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-025-10270-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1444986"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116990"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA00371C"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129905"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym14163260"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39410-0"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.11.041"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.98149"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.109890"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c06168"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2024.116191"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07062-1"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1857330"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2023.04.031"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1156637"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97217-7"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144855"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.04.008"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282261443995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282261443995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282261443995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:19:48Z","timestamp":1789042788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282261443995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/08853282261443995"],"URL":"https:\/\/doi.org\/10.1177\/08853282261443995","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}