{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:07:18Z","timestamp":1790082438967,"version":"4.0.1"},"reference-count":58,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2021-07-6"],"award-info":[{"award-number":["320.6750.2021-07-6"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    The treatment of infected skin wounds remains a significant clinical challenge due to bacterial infection, delayed healing, and the rise of antibiotic-resistant bacteria. This study aims to develop a dual-crosslinked hydrogel dressing with integrated antibacterial and pro-healing functions to promote the regeneration of infected wounds. A dual-network hydrogel (CC\/Cu\n                    <jats:sup>2+<\/jats:sup>\n                    gel) was fabricated through the self-assembly of porcine small intestinal submucosa (SIS) collagen and subsequent ionic crosslinking between chitosan and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    . The material\u2019s microstructure, mechanical properties, cytocompatibility, hemocompatibility, and antibacterial activity against S.aureus and E.coli were systematically characterized. The efficacy in promoting infected wound healing was evaluated using a full-thickness skin defect model in Bama miniature pigs. The incorporation of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    formed a denser polymer network, significantly enhancing the compressive modulus and strength of the hydrogel. The CC\/Cu\n                    <jats:sup>2+<\/jats:sup>\n                    -5 gel formulation demonstrated effective antibacterial activity while maintaining acceptable cytocompatibility and hemocompatibility. In vitro, it facilitated fibroblast proliferation, collagen expression, and angiogenesis. In vivo, it accelerated wound closure, achieving a 98.97% healing rate within 24 days, and promoted well-structured epidermal and dermal regeneration, as confirmed by histological and immunofluorescent analyses. The CC\/Cu\n                    <jats:sup>2+<\/jats:sup>\n                    dual-crosslinked hydrogel, leveraging the synergistic effect of SIS collagen and copper ions, represented a promising functional dressing for managing infected wounds.\n                  <\/jats:p>","DOI":"10.1177\/08853282261449328","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:49:21Z","timestamp":1777967361000},"page":"744-756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A dual-network SIS collagen\/chitosan hydrogel with integrated antibacterial and regenerative functions for infected wound repair"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2567-5452","authenticated-orcid":false,"given":"Ang","family":"Li","sequence":"first","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwen","family":"Jia","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouwen","family":"Qu","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0946"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000396300.04173.ec"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b01149"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119599"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau9533"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328219873254"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27385"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101032"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027083"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100098"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2014.0086"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b01953"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.139486"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123161"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b09640"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00224H"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2004.05.022"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201907042"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202509183"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.08.199"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.08.030"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym15010144"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419170"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc37762h"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100447"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500712"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.008"},{"key":"e_1_3_5_30_2","first-page":"1","article-title":"Infection-responsive long-term antibacterial bone plates for open fracture therapy","volume":"25","author":"Zhang L","year":"2023","unstructured":"Zhang L, Yang Y, Xiong Y-H, et al. 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