{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:09:21Z","timestamp":1790082561177,"version":"4.0.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Natural Science Foundation of Tibet Autonomous Region","award":["XZ202501ZR0090"],"award-info":[{"award-number":["XZ202501ZR0090"]}]},{"name":"Key Research and Development Technology project of Anhui Province","award":["2022j11020013"],"award-info":[{"award-number":["2022j11020013"]}]},{"name":"The College Students\u2019 Innovation and Entrepreneurship Training Project of Anhui Province","award":["S202410366013"],"award-info":[{"award-number":["S202410366013"]}]},{"name":"The Natural Science Foundation for Group-style Medical Aid Project of Tibet Autonomous Region","award":["XZZR202402034[W]"],"award-info":[{"award-number":["XZZR202402034[W]"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    This study aimed to develop a novel topical treatment for\u00a0Pseudomonas aeruginosa\u00a0(\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    )-induced bacterial keratitis (BK) using silver nanoparticles (Ag NPs), addressing critical limitations of current antibiotics, such as poor ocular penetration and microbial resistance. Ag NPs were synthesized via silver-cysteine conjugation and characterized by UV-Vis spectroscopy, zeta potential, dynamic light scattering (DLS), TEM, XRD, and XPS. In vitro, the nanoparticles exhibited potent antibacterial activity against\u00a0\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    \u00a0with minimal cytotoxicity toward human corneal epithelial cells (HCECs). Notably, they also retained observable activity against methicillin-resistant\u00a0Staphylococcus aureus\u00a0(MRSA), suggesting potential for addressing drug-resistant infections. In a mouse model of\u00a0\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    -induced bacterial keratitis, topical application of the Ag NPs effectively ameliorated the infection without harming healthy ocular tissues, demonstrating favorable biocompatibility and strong therapeutic potential. Overall, Ag NPs represent a promising topical nanotherapeutic for BK, offering enhanced ocular bioavailability, retained activity against drug-resistant strains, and favorable biocompatibility, highlighting their strong potential for clinical translation in ocular infection management.\n                  <\/jats:p>","DOI":"10.1177\/08853282261456461","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T21:40:35Z","timestamp":1780004435000},"page":"732-743","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of bacterial keratitis in mouse using Ag nanoparticles suspension"],"prefix":"10.1177","volume":"41","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhezhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Hefei Comprehensive National Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5617-4791","authenticated-orcid":false,"given":"Dongwei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University"},{"name":"Shannan People\u2019s Hospital of Tibet"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.08.007"},{"key":"e_1_3_7_3_2","first-page":"275","article-title":"Antimicrobial peptides loaded collagen nanosheets with enhanced antibacterial activity, corneal wound healing and M1 macrophage polarization in bacterial keratitis","author":"Huang H","year":"2024","unstructured":"Huang H, Xie Y, Zhong J, et al. 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