{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:32Z","timestamp":1792787732305,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Natural Science Foundation of Shandong Province","award":["ZR2023MH018"],"award-info":[{"award-number":["ZR2023MH018"]}]},{"name":"Jining Medical College high-level scientific research project cultivation plan","award":["JYGC2022 KJ007"],"award-info":[{"award-number":["JYGC2022 KJ007"]}],"id":[{"id":"https:\/\/ror.org\/03zn9gq54","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    Osteoporosis treatment using alendronate (ALN) is limited by poor oral bioavailability and gastrointestinal side effects. To address this limitation, this study developed a graphene oxide (GO)-enhanced soluble microneedle (MN) system for transdermal administration of ALN to treat osteoporosis. The MNs were fabricated from polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) using a two-step casting method, forming a drug-loaded core\u2013barrier outer layer. The incorporation of GO significantly improved mechanical strength, with penetration efficiency reaching 66\u223c88%, and enhanced swelling capacity (PP\/GO-ALN swelling ratio: 299%). In vitro release studies showed no significant difference between PP-ALN and PP\/GO-ALN MNs in a dialysis bag model, while ex vivo skin permeation demonstrated that PP\/GO-ALN MNs achieved significantly higher cumulative drug permeation (1069.53\u00a0\u00b5g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) over 24 h compared to PP-ALN MNs (712.89\u00a0\u00b5g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ). Furthermore, GO conferred notable antibacterial activity, and the PP\/GO-ALN formulation synergistically promoted osteoblast proliferation (cell viability: 107.42%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). These findings demonstrate that the GO-ALN MN system possesses mechanical properties, transdermal delivery, antibacterial effects, and biocompatibility. It provides a highly promising non-invasive strategy for the treatment of osteoporosis.\n                  <\/jats:p>","DOI":"10.1177\/08853282261457811","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:16:51Z","timestamp":1780431411000},"page":"659-670","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Graphene oxide-enhanced dissolvable microneedles for transdermal delivery of alendronate: Augmented permeation and antibacterial activity"],"prefix":"10.1177","volume":"41","author":[{"given":"Qianqian","family":"Sun","sequence":"first","affiliation":[{"name":"Jining Medical University"},{"name":"Shandong Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Li","sequence":"additional","affiliation":[{"name":"Jining Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jining Medical University"},{"name":"Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Jining Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlian","family":"Niu","sequence":"additional","affiliation":[{"name":"Jining Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Wang","sequence":"additional","affiliation":[{"name":"Jining Medical University"},{"name":"Shandong Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-4633","authenticated-orcid":false,"given":"Mei","family":"Lv","sequence":"additional","affiliation":[{"name":"Jining Medical University"},{"name":"Shandong Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.62347\/MFPV8667"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116732"},{"key":"e_1_3_4_4_2","first-page":"2490586","article-title":"Exploring UV spectroscopic approaches for alendronate sodium quantification in pharmaceutical and biological samples","volume":"10","author":"Mary A","year":"2025","unstructured":"Mary A, Reddy SG, Kumar BS, et al. 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