{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:54:11Z","timestamp":1790952851743,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"publisher","award":["Ag. Ed.\/27\/05\/NP\/2023\/HRD"],"award-info":[{"award-number":["Ag. Ed.\/27\/05\/NP\/2023\/HRD"]}],"id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"abstract":"<jats:p>\n                    Burn injuries are a major global public health crisis and pose significant problems with limited treatment options due to poor angiogenesis and antimicrobial resistance. To overcome these challenges, a new composite comprising fish collagen (waste-derived), carrageenan, and bioactive glass doped with Zn and\/or Mn was developed. FTIR spectroscopy confirmed the presence of functional groups, while XRD patterns indicate the degree of crystallinity in the formulations. The composite hydrogels are highly hemocompatible, with a hemolysis index of &lt;1%. SEM and EDX analyses revealed a mesoporous surface in composite films containing bioactive glass nanoparticles (Zn and\/or Mn). Dual-doped bioactive glass enhances the formulation\u2019s antimicrobial activity against both Gram-positive and Gram-negative bacteria. The cell viability assays (MTT and FDA) confirm the non-toxicity of the composite gels on human dermal fibroblasts.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    assessment in an animal burn wound model with dual doping of Mn and Zn shows accelerated wound contraction, consistent fibroblast proliferation, minimal inflammation, advanced collagen organization, and epithelial regeneration. The results are further correlated with elastin production and immunohistochemical analysis for CD31 and collagen type-1, inferring promising wound-healing activity. This research showcases a smart, innovative, and powerful approach to developing advanced hydrogel dressings for treating burn wounds and complicated skin injuries.\n                  <\/jats:p>","DOI":"10.1177\/08853282261494282","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:45:26Z","timestamp":1790685926000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of Manganese (Mn) and Zinc (Zn) ion-doped bioactive glass-based fish collagen-carrageenan biomatrix in tissue remodeling of burn wounds"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-4546","authenticated-orcid":false,"given":"Samit Kumar","family":"Nandi","sequence":"first","affiliation":[{"name":"West Bengal University of Animal and Fishery Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0961-2"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2005.08.023"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00672"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2022.10.015"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21210"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050876"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/md12125881"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115596"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42235-021-00105-9"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00179.x"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21728"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-025-04873-x"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2021-0038"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101515"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215584887"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.03.273"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.037"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00727"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102165"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biteb.2023.101344"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.08.021"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02816-0"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33655"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3069-x"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200390166"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.12.003"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-021-00404-6"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2020.53.10.120"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-018-0031-x"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12338"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7172-5_4"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot073411"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1050-2_3"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13400"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3629"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015264"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_866_23"},{"issue":"5","key":"e_1_3_7_39_2","first-page":"373","article-title":"Quantitative analysis of inflammatory cell influx, procollagen type I synthesis, and collagen cross-linking in incisional wounds: influence of PDGF-BB and TGF-\u03b21 therapy","volume":"117","author":"Pierce GF","year":"1991","unstructured":"Pierce GF, Brown D, Mustoe TA. 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