{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:47:36Z","timestamp":1777520856077,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5_suppl","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>A major source of limitation to the real effectiveness of antipsychotics is the high rate of patient nonadherence or, more frequently, partial adherence. using long-acting injectable (LAI) formulations is likely to reduce the impact of such adherence problems. Conversely, the use of LAIs in Canada remains low relative to many other jurisdictions.<\/jats:p>\n                  <jats:p>Based on effectiveness data from randomized control trials and other, less rigorous, studies, as well as our 2 qualitative studies exploring numerous issues around the use of LAIs, including their low use, we put forward 10 different recommendations for consideration by clinicians. These are also based on the experience of many clinicians and clinician scientists. These recommendations address mostly clinical challenges associated with the use of LAIs. Their application in clinical settings is illustrated in our report through several case examples highlighting the large variation across patients and different phases of illness. It is recommended that LAIs should be considered as a treatment option for psychotic disorders across all phases, including the first 2 to 5 critical years.<\/jats:p>","DOI":"10.1177\/088740341305805s05","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T08:07:01Z","timestamp":1486454821000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Long-Acting Injectable Antipsychotics: Recommendations for Clinicians"],"prefix":"10.1177","volume":"58","author":[{"given":"Ashok","family":"Malla","sequence":"first","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, Quebec; Director, Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Tibbo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia; Director, Nova Scotia Early Psychosis Program, Halifax, Nova Scotia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Chue","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, Quebec; Psychiatrist, Prevention and Early Intervention Program for Psychoses, Douglas Mental Health university Institute, Montreal, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Western University, London, Ontario; Director, Prevention and Early Intervention Program for Psychoses, London Health Sciences Centre, London, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Teehan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia; Staff Psychiatrist, Capital District Health Authority, Halifax, Nova Scotia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Williams","sequence":"additional","affiliation":[{"name":"Schizophrenia Service, Vancouver Island Health Authority, Victoria, British Columbia; Adjunct Professor of Psychology, University of Victoria, Victoria, British Columbia; Clinical Professor, Department of Psychiatry, university of British Columbia, Victoria, British Columbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srividya","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University, Montreal, Quebec; Program Coordinator, Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Andr\u00e9","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Faculty of Medicine, Universit\u00e9 Laval, Quebec, Quebec; Head, Clinical and Cognitive Neuroscience Division, Centre de Recherche de l'Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec, Quebec, Quebec; Head, Psychotic Disorders Program, Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec, Quebec, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"bibr1-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000297663"},{"key":"bibr2-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.05.024"},{"key":"bibr3-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.6.506"},{"key":"bibr4-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1177\/088740341305805s02"},{"key":"bibr5-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1177\/088740341305805s03"},{"key":"bibr6-088740341305805s05","doi-asserted-by":"publisher","DOI":"10.1177\/070674370905400106"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088740341305805s05","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088740341305805s05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:12:34Z","timestamp":1777392754000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088740341305805s05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":6,"journal-issue":{"issue":"5_suppl","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1177\/088740341305805s05"],"URL":"https:\/\/doi.org\/10.1177\/088740341305805s05","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}