{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:26:37Z","timestamp":1777379197645,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Zhejiang Provincial Key Laboratory Construction Project","award":["2024ZY01026"],"award-info":[{"award-number":["2024ZY01026"]}]},{"name":"the Construction Fund of Key Medical Disciplines of Hangzhou","award":["2025HZGF13"],"award-info":[{"award-number":["2025HZGF13"]}]},{"name":"the Zhejiang Provincial Science and Technology Program for Disease Prevention and Control","award":["2025JK046"],"award-info":[{"award-number":["2025JK046"]}]},{"name":"Zhejiang Provincial Science and Technology Program for Disease Prevention and Control","award":["2026JKY099"],"award-info":[{"award-number":["2026JKY099"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>\n                    The number and proportion of HIV\/AIDS cases among older people in China have increased continuously and rapidly in recent years, with a more pronounced increase in males. In this study, we report a novel HIV-1 second-generation unique recombinant form isolated from a 79-year-old man in Hangzhou, for whom nonmarital commercial heterosexual contact as the potential transmission route. Phylogenetic analysis of the near full-length genome (NFLG) of strain 24HZ0410 reveals that a small genomic segment of CRF01_AE is inserted into the CRF07_BC backbone. Two recombinant breakpoints were observed in the\n                    <jats:italic toggle=\"yes\">tat<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">env<\/jats:italic>\n                    gene regions, respectively. Our findings provide insight and a scientific basis in the genetic diversity in China. In addition, further molecular epidemiological surveillance of HIV-1 should be emphasized and strengthened among the elderly population in this region.\n                  <\/jats:p>","DOI":"10.1177\/08892229261416191","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:51:09Z","timestamp":1769583069000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a Novel HIV-1 Recombinant Form (CRF01_AE\/07_BC) from an Elderly Individual in Hangzhou, Eastern China"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-3545","authenticated-orcid":false,"given":"Ling","family":"Ye","sequence":"first","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."},{"name":"Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."},{"name":"Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."},{"name":"Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.12.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.5.2472-2482.2006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.12.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000131330.28762.0c"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047289"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0029"},{"key":"e_1_3_3_8_2","unstructured":"HIV sequence database: HIV Circulating Recombinant Forms (CRFs). Available at sequence\/HIV\/CRFs\/CRFs.Html[Last accessed: October14 2024]."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20146-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02455-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.18.1.20035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1371675"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19279"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1475548"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2023.0066"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112866-20220325-00069"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08892229261416191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08892229261416191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08892229261416191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:13:32Z","timestamp":1777367612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08892229261416191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1177\/08892229261416191"],"URL":"https:\/\/doi.org\/10.1177\/08892229261416191","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}