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In this study, HIV-1 samples were collected from two male patients in Shenzhen, China. Two novel recombinant forms (Ls6449 and Ls16801) derived from CRF01_AE and CRF07_BC were identified, and their near full-length genomes were obtained. Analysis of these two forms suggested that the recombination between CRF01_AE and CRF07_BC continued to occur in Shenzhen, potentially contributing to the increasing genetic complexity of the local HIV-1 epidemic. These findings highlight the need for enhanced molecular surveillance and genotyping targeting key routes, specifically sexual transmission and mobility-associated spread. It is expected to generate precise epidemiological evidence and inform local HIV prevention and control strategies.<\/jats:p>","DOI":"10.1177\/08892229261471606","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:38:13Z","timestamp":1784871493000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Characterization of Two Novel HIV-1 CRF01_AE\/CRF07_BC Unique Recombinant Forms in Shenzhen, China"],"prefix":"10.1177","volume":"42","author":[{"given":"Dandan","family":"Lin","sequence":"first","affiliation":[{"name":"School of Public Health, Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, China."},{"name":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 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