{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:26:29Z","timestamp":1793568389488,"version":"4.5.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    In this study, the relationship between the allele and genotype frequencies of the rs7975232 (ApaI) and rs731236 (TaqI) polymorphisms of the vitamin D receptor (\n                    <jats:italic toggle=\"yes\">VDR<\/jats:italic>\n                    ) gene and country-based HIV\/AIDS prevalence and mortality rates were examined using Spearman rank correlation analyses. These Spearman analyses were validated for significance using the False Discovery Rate (FDR) method, considering traditional criteria (Adjusted\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value &lt;.05). The findings revealed that ApaI_CC and TaqI_TT genotype frequencies showed weak inverse correlations with HIV\/AIDS prevalence and mortality rates (\u03c1 \u2248 \u20130.30 and \u20130.25); however, these correlations were not statistically significant after FDR correction (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    _adj &gt; 0.05). These results suggest that\n                    <jats:italic toggle=\"yes\">VDR<\/jats:italic>\n                    polymorphisms showed no statistically significant association with HIV\/AIDS epidemiology in this ecological analysis; at most, these findings generate a population-level hypothesis that vitamin D\u2013mediated immune responses may warrant further study. These findings should be regarded as exploratory and hypothesis-generating, and may inform future individual-level genotype\u2013phenotype and functional studies.\n                  <\/jats:p>","DOI":"10.1177\/08892229261487810","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:05:06Z","timestamp":1789967106000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of rs7975232 (ApaI) and rs731236 (TaqI)\n                    <i>VDR<\/i>\n                    Polymorphisms on HIV\/AIDS Prevalence and Mortality: An International Population Genetics Analysis"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-9687","authenticated-orcid":false,"given":"Nermin","family":"Akcali","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Bandirma Onyedi Eylul University, Balikesir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00fcneyd","family":"Yavas","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Eslamkhah","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonat Sina","family":"Canturk","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser","family":"Eryildiz","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa","family":"Aslan","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Nur","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfiye","family":"Karcioglu Batur","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Science, Biruni University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.Joint United Nations Programme on HIV\/AIDS. 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Available from: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_FactSheet_en.pdf [Last accessed: December9 2025]."},{"key":"e_1_3_3_8_1","first-page":"1","volume-title":"The global epidemiology of HIV\/AIDS. \u0130\u00e7inde: Global HIV\/AIDS Medicine","author":"DeCock KM","year":"2008","unstructured":"7.DeCock KM. The global epidemiology of HIV\/AIDS. \u0130\u00e7inde: Global HIV\/AIDS Medicine. (Volberding PA, , Sande MA, , Greene WC, , Lange JMA, , Gallant JE, , Walsh CC., eds.) W.B. Saunders: Philadelphia; 2008; s. 1\u201312."},{"key":"e_1_3_3_9_1","unstructured":"8.World Health Organization. HIV\/AIDS. Geneva Switzerland; 2023. 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