{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:26:31Z","timestamp":1793568391760,"version":"4.5.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    HIV infection remains a significant public health challenge. Although antiretroviral therapy has substantially improved survival, chronic complications such as renal impairment increase morbidity and mortality, making the estimated glomerular filtration rate (eGFR) crucial for early detection. This prospective, observational, and analytical cohort study aimed to identify the clinical, sociodemographic, and laboratory factors associated with short-term eGFR decline in people living with HIV (PLWH) over a 6-month follow-up at a second-level Mexican hospital. We included 166 PLWH aged &gt; 18 years, collecting data on serum creatinine, eGFR, viral load, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell counts. Patients were stratified based on the magnitude of eGFR decline into four groups (&lt;5, 5\u20139, 10\u201319, and \u226520 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    ). The median age was 35 years (91% male). Median eGFR was 101.81 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    at baseline and 100.54 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    at 6 months. Most patients achieved virological suppression, and only 2.4% developed chronic kidney disease. Group analysis revealed a significant association between a greater short-term eGFR decline and advanced age, unemployment, and opportunistic infections. In conclusion, short-term renal decline was primarily associated with older age and unemployment. Although chronic kidney disease incidence was low, evaluating short-term eGFR decline allowed for the identification of clinically relevant alterations, highlighting the importance of periodic renal monitoring, particularly in clinically and socially vulnerable patients.\n                  <\/jats:p>","DOI":"10.1177\/08892229261487815","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:32:40Z","timestamp":1789039960000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Factors Associated with Short-Term Decline in Estimated Glomerular Filtration Rate in People Living with HIV Receiving Antiretroviral Therapy: A Prospective Cohort Study"],"prefix":"10.1177","volume":"42","author":[{"given":"Xenia","family":"Choc-Cano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Hospital General de Zona 18, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricarmen","family":"Pelayo-Madrigal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Hospital General de Zona 18, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Guti\u00e9rrez-Maya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Hospital General de Zona 18, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Zepeda-Quiroz","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hospital de Traumatolog\u00eda y Ortopedia \u201cDr. y Gral. Rafael Moreno Valle\u201d, Instituto Mexicano del Seguro Social para el Bienestar, Puebla, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Toledo-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General Regional 17, Instituto Mexicano del Seguro Social, Cancun, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrera-Mota","family":"Brenda","sequence":"additional","affiliation":[{"name":"Planning and Institutional Liaison Coordinator, Hospital General Regional 17, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimenez-Baez","family":"Valeria","sequence":"additional","affiliation":[{"name":"Planning and Institutional Liaison Coordinator, Hospital General Regional 17, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciria","family":"V\u00e1zquez-Macias","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital General de Zona 18, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-8935","authenticated-orcid":false,"given":"Daniel","family":"Ju\u00e1rez-Villa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Hospital General de Zona 18, Instituto Mexicano del Seguro Social, Playa del Carmen, Quintana Roo, Mexico."},{"name":"Department of Nephrology, Hospital General de Playa del Carmen, Instituto Mexicano del Seguro Social para el Bienestar, Playa del Carmen, Quintana Roo, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.UNAIDS\/WHO estimates. HIV data and statistics [Internet]. Geneva: World Health Organization; 2025. Available from: https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/strategic-information\/hiv-data-and-statistics [Last accessed: August8 2025]."},{"key":"e_1_3_3_3_1","unstructured":"2.Secretar\u00eda de Salud. Direcci\u00f3n General de Epidemiolog\u00eda. Informe hist\u00f3rico VIH D\u00eda Mundial 2025 [Internet]. Ciudad de M\u00e9xico: Secretar\u00eda de Salud; 2025. Available from: https:\/\/www.gob.mx\/cms\/uploads\/attachment\/file\/1039910\/DVEET_Informe_Historico_VIH_2025_DIAMUNDIAL.pdf [Last accessed: August8 2025]."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11020197"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-JBN-2018-0024"},{"issue":"1","key":"e_1_3_3_6_1","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","unstructured":"5.Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013;3(1):1\u2013150.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-025-07624-2"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S243913"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2023.0032"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03761-1"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939-020-01356-4"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000094"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02526-4"}],"container-title":["AIDS Research and Human Retroviruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08892229261487815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08892229261487815","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08892229261487815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:49:31Z","timestamp":1793566171000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08892229261487815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12,1]]}},"alternative-id":["10.1177\/08892229261487815"],"URL":"https:\/\/doi.org\/10.1177\/08892229261487815","relation":{},"ISSN":["0889-2229","1931-8405"],"issn-type":[{"value":"0889-2229","type":"print"},{"value":"1931-8405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}