{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:33:35Z","timestamp":1793205215043,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIAID\/BEAT-HIV Collaboratory","award":["UM1AI164570"],"award-info":[{"award-number":["UM1AI164570"]}]},{"name":"National Institute of Mental Health","award":["R21-MH132406"],"award-info":[{"award-number":["R21-MH132406"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    Human immunodeficiency virus (HIV) persists in diverse body tissues, including the gut, lymph nodes (LNs), and lungs, requiring direct sampling to characterize heterogeneous reservoirs. HIV cure\u2013related trials may include tissue sampling to evaluate intervention efficacy and mechanisms to eliminate viral reservoirs. Repeated invasive sampling carries risks that must be balanced against safety, acceptability, and scientific value. We assessed the experiences of young women undergoing serial excisional LN and gut biopsies during an HIV cure\u2013related trial in South Africa. We conducted a qualitative secondary analysis of in-depth interviews (IDIs) with women enrolled in a Phase 2A HIV cure\u2013related trial (NCT05281510) that included an analytical treatment interruption (ATI). We conducted IDIs at enrollment and pre-ATI at the Females Rising through Education, Support and Health research site in Durban, South Africa, in\n                    <jats:italic toggle=\"yes\">isiZulu<\/jats:italic>\n                    . We audio-recorded, transcribed, translated, and deidentified the interviews and analyzed them using inductive conventional content analysis. We interviewed 19 participants. Each underwent LN excision 1\u20133 times (mean 2.6) and gut biopsy 0\u20133 times (mean 2.5). Motivations included scientific curiosity and contributing to future generations. LN excision was generally painless, although some reported itching and slow healing. Gut biopsies caused abdominal pressure and transient bloating. One adverse event occurred among 48 LN excisions. Initial apprehension was common, but clear communication, supportive staff, and recognition of contributions fostered trust and willingness to undergo repeat procedures. Serial tissue sampling was acceptable among young South African women despite some discomfort. Altruism was a primary motivator, while clear communication and participant-centered care were critical to supporting informed participation and repeat sampling.\n                  <\/jats:p>","DOI":"10.1177\/08892229261491477","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:10:07Z","timestamp":1790323807000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Experiences and Acceptability of Serial Lymph Node and Gut Biopsies Among Young Women Enrolled in an HIV Cure\u2013Related Trial in Durban, South Africa"],"prefix":"10.1177","volume":"42","author":[{"given":"Mzwakhe Wiseman","family":"Ngcobo","sequence":"first","affiliation":[{"name":"Integration of TB in Education and Care for HIV\/AIDS (ITEACH), Pietermaritzburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntombifuthi","family":"Langa","sequence":"additional","affiliation":[{"name":"Integration of TB in Education and Care for HIV\/AIDS (ITEACH), Pietermaritzburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayanda","family":"Zulu","sequence":"additional","affiliation":[{"name":"Integration of TB in Education and Care for HIV\/AIDS (ITEACH), Pietermaritzburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego (UCSD), La Jolla, California, USA."},{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Pillay","sequence":"additional","affiliation":[{"name":"Females Rising through Education, Support and Health (FRESH), Durban, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Mthembu","sequence":"additional","affiliation":[{"name":"Department of Social Work, School of Applied Human Sciences, University of KwaZulu-Natal (UKZN), Durban, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihle","family":"Ngcongo","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Programme (HPP), The Doris Duke Medical Research Institute, Durban, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego (UCSD), La Jolla, 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Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha L.","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc., Foster City, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc., Foster City, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vendrame","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc., Foster City, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thumbi","family":"Ndung\u2019u","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Programme (HPP), The Doris Duke Medical Research Institute, Durban, South Africa."},{"name":"Africa Health Research Institute (AHRI), Durban, South Africa."},{"name":"Ragon Institute of Mass General Brigham, MIT and Harvard, Cambridge, 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