{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:09:11Z","timestamp":1784117351867,"version":"3.55.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Health Promot"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Explore the causal relationship between sedentary behavior (SB) and the new onset of chronic pain (NOCP) in Americans aged \u226550\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective secondary data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Sample<\/jats:title>\n                    <jats:p>In a target trial emulation framework, a dataset comprising four consecutive waves (2012, 2014, 2016, and 2018) from the longitudinal Health and Retirement Study was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measures\/Analysis<\/jats:title>\n                    <jats:p>Univariable and multivariable analyses were conducted using survey-weighted, mixed-effects Poisson regression models with one-level random intercepts and linearized standard errors. Using the same approach, causal mediation analyses were carried out to examine the potential role of obesity, depression, and sleep disturbances as mediators in the relationship between SB and NOCP. The role of education level, race, and sex as potential effect modifiers was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the multivariable analysis, the risk of NOCP in participants who reported not having pain in the 2012 interview increased by 22% in those with SB vs those reporting no SB (95% CI = 1.12, 1.33;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). The mediation effect attributed to obesity and depression was 58.2% (95% CI = 50.5, 71.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and 8.8% (95% CI = 1.6, 14.1;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), respectively. The risk of NOCP in participants reporting SB was increased by 24.8% in women vs men (incidence rate ratio 1.25; 95% CI = 1.02, 1.52;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      There is strong evidence for an association between SB and NOCP in the American subpopulation of women aged\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mo>\u2265<\/mml:mo>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      50\u00a0years. This effect seems to be mainly mediated by obesity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08901171251412951","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T12:58:55Z","timestamp":1766926735000},"page":"820-831","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Sedentary Behavior and the Development of New-Onset Chronic Pain in Older American Adults: Insights From the Health and Retirement Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-9307","authenticated-orcid":false,"given":"Wilson","family":"Fandino","sequence":"first","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-5322","authenticated-orcid":false,"given":"Karla Loureiro","family":"Loss","sequence":"additional","affiliation":[{"name":"Federal University of Espirito Santo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-0073","authenticated-orcid":false,"given":"Nuno V.","family":"Gomes","sequence":"additional","affiliation":[{"name":"University Hospital Basel"},{"name":"University of Basel"},{"name":"Department of Anaesthesia and Intensive Care, Royal Papworth Hospital NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-0514","authenticated-orcid":false,"given":"Jos\u00e9 Armando","family":"Garc\u00eda Delgado","sequence":"additional","affiliation":[{"name":"Hospitalization Department, Instituto Nacional Del C\u00e1ncer Rosa Emilia S\u00e1nchez de T., INCART"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Daudt de Faro","family":"Salamonde","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina S\u00e3o Leopoldo Mandic, SLMandic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-6349","authenticated-orcid":false,"given":"Blanca","family":"Baz\u00e1n-Perkins","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas"},{"name":"Departament of Basic Sciences, Tecnol\u00f3gico de Monterrey, Escuela de Medicina y Ciencias de La Salud"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pacheco-Barrios","sequence":"additional","affiliation":[{"name":"Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[{"name":"Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_3_6_2_2","article-title":"Chronic pain among adults \u2014 United States, 2019\u20132021","author":"Rikard SM","unstructured":"Rikard SM. 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