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In total, 199 women were randomly allocated to 3 groups and supplemented in the postpartum period with a single retinyl palmitate dose of 200 000 IU (S1), a double dose of 200 000 IU 24 hours apart (S2), or no supplementation (C). Retinol content of colostrum and mature milk at 4 weeks was determined by high-performance liquid chromatography (HPLC). For colostrum, no significant difference was found between the groups ( P = .965). The retinol content in mature milk differed between group C and groups S1 and S2 ( P &lt; .05). The double dose of vitamin A did not significantly increase the retinol content of milk at 4 weeks postpartum in comparison to a single dose; however, future research is needed to determine the optimal timing of the second dose of vitamin A.<\/jats:p>","DOI":"10.1177\/0890334409356445","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T22:45:50Z","timestamp":1264718750000},"page":"148-156","source":"Crossref","is-referenced-by-count":20,"title":["A Randomized Trial Evaluating the Effect of 2 Regimens of Maternal Vitamin A Supplementation on Breast Milk Retinol Levels"],"prefix":"10.1177","volume":"26","author":[{"given":"Danielle Soares","family":"Bezerra","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Cultura e Extens\u00e3o do Rio Grande do Norte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine Feitosa","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle Mahara Martins","family":"Azev\u00eado","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Dimenstein","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Federal University of Rio Grande do Norte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665100000161"},{"key":"atypb2","first-page":"305","volume":"78","author":"Goodman T.","year":"2000","journal-title":"Bull World Health Organ"},{"key":"atypb3","volume-title":"Indicators for Assessing Vitamin A Deficiency and Their Application for Monitoring and Evaluating Interventions Programmes: Micronutrient Series","author":"World Health Organization (WHO).","year":"1996"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.4.666"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)02487-8"},{"key":"atypb6","first-page":"5","volume":"8","author":"Muhilal PD","year":"1985","journal-title":"Penelit. 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