{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:35:06Z","timestamp":1782549306294,"version":"3.54.5"},"reference-count":4,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hum Lact"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>\n                    Carboplatin is an alkylating agent that is FDA approved for the treatment of advanced ovarian cancer. Paclitaxel is a plant taxane mitotic inhibitor approved for primary or salvage treatment of ovarian and breast cancer. This is a case report of a 40-year-old woman who was exclusively breastfeeding prior to being treated for papillary thyroid cancer with intravenous carboplatin (233 mg) and intravenous paclitaxel (30 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) for 6 consecutive weeks. Breast milk samples were collected during the sixth chemotherapy session. Carboplatin had a relative infant dose of 2.0% and remained measurable after 316 hours. Paclitaxel had a relative infant dose of 16.7% but was eliminated before 316 hours. The potential side effects of infant exposure of these medications include myelosuppression, hypersensitivity reactions, nephrotoxicity, and neurotoxicity. It would be inadvisable for a mother to breastfeed while undergoing therapy with these 2 medications.\n                  <\/jats:p>","DOI":"10.1177\/0890334412459374","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T20:48:52Z","timestamp":1350593332000},"page":"457-459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Transfer of Carboplatin and Paclitaxel into Breast Milk"],"prefix":"10.1177","volume":"28","author":[{"given":"Stephen J.","family":"Griffin","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Center at Amarillo, Amarillo, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Milla","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center at Amarillo, Amarillo, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa E.","family":"Baker","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center at Amarillo, Amarillo, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjia","family":"Liu","sequence":"additional","affiliation":[{"name":"International RINP, Inc, Laguna Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[{"name":"International RINP, Inc, Laguna Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Hale","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center at Amarillo, Amarillo, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,18]]},"reference":[{"key":"bibr1-0890334412459374","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273422"},{"key":"bibr2-0890334412459374","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855010-00002"},{"key":"bibr3-0890334412459374","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.8.1232"},{"key":"bibr4-0890334412459374","first-page":"192","volume-title":"Drugs and Human Lactation","author":"Bennett PN","year":"1996","edition":"2"}],"container-title":["Journal of Human Lactation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0890334412459374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0890334412459374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0890334412459374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:34:29Z","timestamp":1777502069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0890334412459374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,18]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1177\/0890334412459374"],"URL":"https:\/\/doi.org\/10.1177\/0890334412459374","relation":{},"ISSN":["0890-3344","1552-5732"],"issn-type":[{"value":"0890-3344","type":"print"},{"value":"1552-5732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,18]]}}}