{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:31:14Z","timestamp":1793107874867,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hum Lact"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Two studies have demonstrated an analgesic effect of maternal milk odor in preterm neonates, without specifying the method of olfactory stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research aim:<\/jats:title>\n                    <jats:p>This study aimed to assess the analgesic effect of maternal milk odor in preterm neonates by using a standardized method of olfactory stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This trial was prospective, randomized, controlled, double blinded, and centrally administered. The inclusion criteria for breastfed infants included being born between 30 and 36 weeks + 6 days gestational age and being less than 10 days postnatal age. There were two groups: (a) A maternal milk odor group underwent a venipuncture with a diffuser emitting their own mother\u2019s milk odor and (2) a control group underwent a venipuncture with an odorless diffuser. The primary outcome was the Premature Infant Pain Profile (PIPP) score, with secondary outcomes being the French scale of neonatal pain\u2014Douleur Aigu\u00eb du Nouveau-n\u00e9 (DAN) scale\u2014and crying duration. All neonates were given a dummy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our study included 16 neonates in the maternal milk odor group and 17 in the control group. Neonates exposed to their own mother\u2019s milk odor had a significantly lower median PIPP score during venipuncture compared with the control group (6.3 [interquartile range (IQR) = 5-10] versus 12.0 [IQR = 7-13], p = .03). There was no significant difference between the DAN scores in the two groups ( p = .06). Maternal milk odor significantly reduced crying duration after venipuncture (0 [IQR = 0-0] versus 0 [IQR = 0-18], p = .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Maternal milk odor has an analgesic effect on preterm neonates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0890334417693225","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T17:38:58Z","timestamp":1490636338000},"page":"300-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":73,"title":["Analgesic Effect of Maternal Human Milk Odor on Premature Neonates: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"33","author":[{"given":"Audrey","family":"Baudesson de Chanville","sequence":"first","affiliation":[{"name":"Department of Neonatology, North Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Brevaut-Malaty","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Garbi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barthelemy","family":"Tosello","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Baumstarck","sequence":"additional","affiliation":[{"name":"Clinical Research Methodology Support Service, Faculty of Medicine, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gire","sequence":"additional","affiliation":[{"name":"Department of Neonatology, North Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain Le","family":"Cozannet","sequence":"additional","affiliation":[{"name":"Aroma Therapeutics, 100 impasse des Houlli\u00e8res-13590 Meyreuil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"bibr1-0890334417693225","doi-asserted-by":"crossref","unstructured":"Aoyama S., Toshima T., Saito Y., Konishi N., Motoshige K., Ishikawa N., Kobayashi M. 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