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A cross-sectional analysis of stress and mood was performed using the Revised Memory and Behavior Problem Checklist and the Geriatric Depression Scale. All subjects were evaluated for normal cognitive function (Mini-Mental Status Examination) and apo E genotype. The results indicated that increased levels of stress were associated with increased levels of depres sive symptoms in nondemented caregivers with the \u22084 allele. This relationship was not observed in caregivers without the \u22084 allele. These results suggest that carriers of the \u22084 allele may respond differently to psychological stress than do individuals without the \u22084 allele. 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