{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:14:11Z","timestamp":1789726451556,"version":"4.0.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>The \u22084 allele of apolipoprotein (apo E) is one of the risk factors for late-onset Alzheimer's disease (AD). We evaluated the association between apo E genotypes and depression in patients with AD. A psychiatrist interviewed all patients and their caregivers for depression using a Chinese version of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, and for the severity of depression using the Hamilton Depression Rating Scale (HDRS). Twenty-five of the 149 patients with AD were diagnosed with depressive disorders. The numbers of patients in each apo E genotype were 10 in \u22082\/3, 2 in \u22082\/4, 74 in \u22083\/3, 46 in \u22083\/4, and 17 in \u22084\/4. We did not find an association between depression and the presence or absence of the \u22084 or \u22082 allele. The HDRS scores were not different in patients with AD with the \u22084 or \u22082 allele or in those patients without them. Our study did not find an association between depression and the apo E \u22084 or \u22082 allele in AD. (J Geriatr Psychiatry Neurol 2002; 15:20-23).<\/jats:p>","DOI":"10.1177\/089198870201500105","type":"journal-article","created":{"date-parts":[[2007,3,11]],"date-time":"2007-03-11T04:39:55Z","timestamp":1173587995000},"page":"20-23","source":"Crossref","is-referenced-by-count":20,"title":["Lack of Association between the Apolipoprotein E Genotype and Depression in Alzheimer's Disease"],"prefix":"10.1177","volume":"15","author":[{"given":"Chia-Yih","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Chang Gung Umversity School of Medicine and Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Jee","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Research and 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