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Given the likelihood that agents will become available that reliably delay onset and\/or slow progression of Alzheimer\u2019s disease, it will be important to detect preclinical Alzheimer\u2019s disease as early as possible for maximal treatment effect. Detection of individuals by sensitive cognitive measures provides one way to identify people who are at high risk of developing clinical Alzheimer\u2019s disease. However, it is likely that those with considerable brain or cognitive reserve will be able to mask cognitive deficits until very close to the onset of the dementia, rendering such cognitive measures insensitive. Optimum biomarkers for Alzheimer\u2019s disease therefore need to target the severity of underlying brain pathology independently of brain reserve. Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.<\/jats:p>","DOI":"10.1177\/0891988705281869","type":"journal-article","created":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T12:54:12Z","timestamp":1132750452000},"page":"218-223","source":"Crossref","is-referenced-by-count":137,"title":["Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression"],"prefix":"10.1177","volume":"18","author":[{"given":"James A.","family":"Mortimer","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Borenstein","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, 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