{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:33:51Z","timestamp":1790379231072,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>Two subtypes of Alzheimer\u2019s disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.<\/jats:p>","DOI":"10.1177\/0891988706297086","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T18:56:26Z","timestamp":1173207386000},"page":"29-33","source":"Crossref","is-referenced-by-count":132,"title":["Early-Onset Alzheimer\u2019s Disease Is Associated With Greater Pathologic Burden"],"prefix":"10.1177","volume":"20","author":[{"given":"Gad A.","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Fairbanks","sequence":"additional","affiliation":[{"name":"Psychiatry and Biobehavioral Neuroscience, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Tekin","sequence":"additional","affiliation":[{"name":"Florham Park, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry V.","family":"Vinters","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pathology and Laboratory Medicine, Neuropathology, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Neurology, Psychiatry and Biobehavioral Neuroscience, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.326"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2002.00385.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.1.48"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200210070-00028"},{"key":"atypb5","first-page":"212","volume":"7","author":"Nochlin D","year":"1993","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"atypb7","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000","edition":"4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-32-CID"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.72"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-004-0084-7"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1_Suppl_1.S2"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.2.165"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0197-4580(97)00057-2","volume":"18","year":"1997","journal-title":"Neurobiol Aging"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35006-4"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(93)90112-O"}],"container-title":["Journal of Geriatric Psychiatry and Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988706297086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988706297086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:18:22Z","timestamp":1777501102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0891988706297086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1177\/0891988706297086"],"URL":"https:\/\/doi.org\/10.1177\/0891988706297086","relation":{},"ISSN":["0891-9887","1552-5708"],"issn-type":[{"value":"0891-9887","type":"print"},{"value":"1552-5708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}