{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:29:33Z","timestamp":1777850973526,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    Although nutrient deficiencies are thought to play roles in the development of depression, observational studies have yielded inconsistent results. This study aimed to investigate whether multiple marginal nutrient deficiencies are associated with symptoms of depression in community-dwelling older Taiwanese. Data from 1371 elderly adults recruited from the Elderly Nutrition and Health Survey in Taiwan was used in this study. Depressive symptom scores on depressed mood and emotions affecting daily life were derived from the Medical Outcomes Study Short Form-36 (SF-36). Hemoglobin, serum ferritin, plasma vitamins B\n                    <jats:sub>6<\/jats:sub>\n                    , B\n                    <jats:sub>12<\/jats:sub>\n                    , and folate concentration, and erythrocyte transketolase and glutathione reductase activation coefficients were measured. After adjusting for age, gender, cognitive function, physical activity, disease history, and medication in the multivariate analysis, anemia, and marginal B\n                    <jats:sub>6<\/jats:sub>\n                    deficiency were significantly associated with the presence of depression symptoms, respectively. In addition, co-occurrence of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    with low folate level and co-occurrence of anemia either with low vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    or with folate level were all associated with the depressive mood and with depressive emotions defined by SF-36 (odds ratios [OR] in the range of 2.32\u22127.13, all P values \u2264.05). The magnitude of the ORs is larger when the number of deficiencies increased. Elderly people with coexisting marginal deficiencies of nutrients involved in the S-adenosylmethionine and hemoglobin production were more likely to experience depressed mood and emotion that affect daily activity. Examining status of these nutrients is worthy of consideration for older adults with depressed symptoms.\n                  <\/jats:p>","DOI":"10.1177\/0891988712458365","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T07:31:41Z","timestamp":1351841501000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Co-occurrence of Anemia, Marginal Vitamin B\n                    <sub>6<\/sub>\n                    , and Folate Status and Depressive Symptoms in Older Adults"],"prefix":"10.1177","volume":"25","author":[{"given":"Wen-Harn","family":"Pan","sequence":"first","affiliation":[{"name":"Nutrition Medicine Research Program, Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Maoli, Taiwan"},{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"},{"name":"Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan"},{"name":"Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ting","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shu","family":"Guei","sequence":"additional","affiliation":[{"name":"Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Fong","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ien-Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Nursing, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feili Lo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Sciences, Fu-Jen University, Hsin-Chung, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Po","family":"Liaw","sequence":"additional","affiliation":[{"name":"Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan"},{"name":"Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hospitality Management, Chung Hwa University of Medical Technology, Tainan County, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,2]]},"reference":[{"key":"bibr1-0891988712458365","volume-title":"Prevention of Mental Disorders: Effective Interventions and Policy Options: Summary Report","author":"World Health Organization, Prevention Research Centre of the Universities of Nijmegen and Maastricht","year":"2004"},{"key":"bibr2-0891988712458365","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7471.895"},{"key":"bibr3-0891988712458365","unstructured":"World Health Organization. Depression. Internet: http:\/\/www.who.int\/mental_health\/management\/depression\/definition\/en. 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