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The utility of 2 validated and data-driven tests (Mini-Addenbrooke\u2019s Cognitive Examination [M-ACE] and Motor Neuron Disease Behavioral Scale [MiND-B]) was investigated in 70 ALS patients (24 ALSFTD, 19 ALS plus, and 27 ALS pure). More than 90% of patients with ALSFTD scored at or below the cutoff on the M-ACE, whereas this was seen in only about 20% of ALS patients without dementia. The MiND-B differentiated between ALS pure and ALS plus diagnostic categories. Rasch modeling of M-ACE and MiND-B items revealed early cognitive (fluency, memory recall) and behavioral (apathy) symptoms in ALSFTD. The combined use of the M-ACE and MiND-B detects patients with ALSFTD, differentiates along the ALS continuum, and offers insight into the progression of nonmotor symptomatology in ALSFTD.<\/jats:p>","DOI":"10.1177\/0891988715598232","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T21:30:23Z","timestamp":1438896623000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Cognitive and Behavioral Symptoms in ALSFTD"],"prefix":"10.1177","volume":"29","author":[{"given":"Sharpley","family":"Hsieh","sequence":"first","affiliation":[{"name":"Brain and Mind Research Institute, Sydney, New South Wales, Australia"},{"name":"Neuroscience Research Australia, Sydney, New South Wales, Australia"},{"name":"ARC Centre of Excellence in Cognition and its Disorders, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jashelle","family":"Caga","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity V. 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