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In this study, we investigated the association between rs2279590, rs11136000, and rs9331888 single-nucleotide polymorphisms (SNPs) in CLU and apolipoprotein E ( APOE) genotypes in a cohort of Turkish patients with late-onset AD (LOAD). There were 183 patients with LOAD and 154 healthy controls included in the study. The CLU and APOE polymorphisms were genotyped using the LightSNiP assay. The \u201cGG\u201d genotype of rs9331888 was significantly more frequent in patients with LOAD. The \u201cCC\u201d genotype of the SNP was significantly more frequent in controls. The rs9331888 \u201cGG\u201d genotype in patients and the \u201cCC\u201d genotype in controls were significantly higher in non-\u220a4 allele carriers of APOE. The haplotype analysis showed the CLU \u201cGCG\u201d haplotype was a risk haplotype. Our findings indicate the rs9331888 SNP of CLU is associated with LOAD independent of APOE.<\/jats:p>","DOI":"10.1177\/0891988716640373","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T20:54:17Z","timestamp":1460580857000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort"],"prefix":"10.1177","volume":"29","author":[{"given":"Merve","family":"Alayl\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Gezen-Ak","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, 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