{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:27:49Z","timestamp":1790227669321,"version":"4.1.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While much disinhibition in dementia results from generalized impulsivity, in behavioral variant frontotemporal dementia (bvFTD) disinhibition may also result from impaired social cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To deconstruct disinhibition and its neural correlates in bvFTD vs. early-onset Alzheimer\u2019s disease (eAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Caregivers of 16 bvFTD and 21 matched-eAD patients completed the Frontal Systems Behavior Scale disinhibition items. The disinhibition items were further categorized into (1) \u201cperson-based\u201d subscale which predominantly associated with violating social propriety and personal boundary and (2) \u201cgeneralized-impulsivity\u201d subscale which included nonspecific impulsive acts. Subscale scores were correlated with grey matter volumes from tensor-based morphometry on magnetic resonance images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In comparison to the eAD patients, the bvFTD patients developed greater person-based disinhibition ( P &lt; 0.001) but comparable generalized impulsivity. Severity of person-based disinhibition significantly correlated with the left anterior superior temporal sulcus (STS), and generalized-impulsivity correlated with the right orbitofrontal cortex (OFC) and the left anterior temporal lobe (aTL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Person-based disinhibition was predominant in bvFTD and correlated with the left STS. In both dementia, violations of social propriety and personal boundaries involved fronto-parieto-temporal network of Theory of Mind, whereas nonspecific disinhibition involved the OFC and aTL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0891988716666377","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T20:39:00Z","timestamp":1474317540000},"page":"344-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Pongsatorn","family":"Paholpak","sequence":"first","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"},{"name":"Department of Psychiatry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"},{"name":"Greater Los Angeles VA Healthcare System, West Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Barsuglia","sequence":"additional","affiliation":[{"name":"Greater Los Angeles VA Healthcare System, West Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Barrows","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"},{"name":"Greater Los Angeles VA Healthcare System, West Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"},{"name":"Greater Los Angeles VA Healthcare System, West Los Angeles, CA, USA"},{"name":"Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Behavioral Health, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"},{"name":"Greater Los Angeles VA Healthcare System, West Los Angeles, CA, USA"},{"name":"Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"bibr1-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"bibr2-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12325"},{"key":"bibr3-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.12.024"},{"key":"bibr4-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0489-x"},{"key":"bibr5-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409001136"},{"key":"bibr6-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1080\/17470919.2011.614004"},{"key":"bibr7-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnn.0000119241.65522.90"},{"key":"bibr8-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1159\/000357838"},{"key":"bibr9-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324920.96835.95"},{"key":"bibr10-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh628"},{"key":"bibr11-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr173"},{"key":"bibr12-0891988716666377","doi-asserted-by":"crossref","unstructured":"Baron-Cohen S. Mindblindness an essay on autism and theory of mind. 1995. Web site. http:\/\/search.ebscohost.com\/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=48513. Updated March 20, 2009. Accessed June 10, 2015.","DOI":"10.7551\/mitpress\/4635.001.0001"},{"key":"bibr13-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.05.001"},{"key":"bibr14-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20547"},{"key":"bibr15-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"bibr16-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6481-y"},{"key":"bibr17-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1177\/1073191102250339"},{"key":"bibr18-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.04.374"},{"key":"bibr19-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"bibr20-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.135.2.226"},{"key":"bibr21-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.08.005"},{"key":"bibr22-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/0001-6918(66)90004-7"},{"key":"bibr23-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8"},{"key":"bibr24-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1080\/09084280802083863"},{"key":"bibr25-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490918444"},{"key":"bibr26-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"bibr27-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02911.x"},{"key":"bibr28-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2001.0080401"},{"key":"bibr29-0891988716666377","first-page":"493","volume":"19","author":"Leow A","year":"2005","journal-title":"Inf Proc Med Imaging"},{"key":"bibr30-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.066"},{"key":"bibr31-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-302087"},{"key":"bibr32-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013070"},{"key":"bibr33-0891988716666377","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131337"},{"key":"bibr34-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12108"},{"key":"bibr35-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.185"},{"key":"bibr36-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.295"},{"key":"bibr37-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1159\/000194658"},{"key":"bibr38-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1159\/000091898"},{"key":"bibr39-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.02.009"},{"key":"bibr40-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.1.53"},{"key":"bibr41-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.06.009"},{"key":"bibr42-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.005"},{"key":"bibr43-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.23.1.74"},{"key":"bibr44-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu003"},{"key":"bibr45-0891988716666377","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00467"},{"key":"bibr46-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1038\/nn1223"},{"key":"bibr47-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1038\/nn0504-422"},{"key":"bibr48-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.024"},{"key":"bibr49-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv111"},{"key":"bibr50-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20148"},{"key":"bibr51-0891988716666377","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.12.001"}],"container-title":["Journal of Geriatric Psychiatry and Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988716666377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0891988716666377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988716666377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:15:29Z","timestamp":1777500929000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0891988716666377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1177\/0891988716666377"],"URL":"https:\/\/doi.org\/10.1177\/0891988716666377","relation":{},"ISSN":["0891-9887","1552-5708"],"issn-type":[{"value":"0891-9887","type":"print"},{"value":"1552-5708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,21]]}}}