{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:01:29Z","timestamp":1790661689824,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Increase in serum homocysteine is shown to be a potential risk factor for cognitive impairment. Evidence suggests that vitamin B supplementation may reduce cognitive decline by lowering the homocysteine levels. The current meta-analysis evaluated the efficacy of folic acid along with vitamin B12 and\/or B6 in lowering homocysteine, thereby attenuating cognitive decline in elderly patients with Alzheimer disease or dementia. Randomized controlled trials (RCTs) comparing the efficacy of folate and B vitamin supplementation in patients with cognitive decline secondary to Alzheimer disease or dementia were identified using the keywords, \u201chomocysteine, hyper-homocysteinemia, B vitamin, vitamin B6, B12, folic acid, cognitive, Alzheimer\u2019s disease, and dementia.\u201d The outcome measures analyzed were the Mini-Mental State Examination (MMSE) score and serum homocysteine. Of the 77 studies identified, 4 RCTs were included in the current meta-analysis. The baseline characteristics, age, and gender distribution of patients among the 2 groups (supplement vs placebo) were comparable. The results reveal that the intervention group achieved significantly greater reduction in homocysteine levels than the control (pooled difference in means = \u22123.625, 95% confidence interval [CI] = \u22125.642 to \u22121.608, P &lt; .001). However, no significant difference in MMSE (pooled difference in means = 0.027, 95% CI = \u22120.518 to 0.573, P = 0.921) was observed between the groups. Taken together, vitamin B supplementation was effective in reducing serum homocysteine levels. However, it did not translate into cognitive improvement, indicating that the existing data on vitamin B-induced improvement in cognition by lowering homocysteine levels are conflicting.<\/jats:p>","DOI":"10.1177\/0891988716673466","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T11:11:28Z","timestamp":1476789088000},"page":"50-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":107,"title":["Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases"],"prefix":"10.1177","volume":"30","author":[{"given":"Dong-Mei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Fuzhou General Hospital of Nanjing Command, PLA and Clinical Medical College of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fuzhou General Hospital of Nanjing Command, PLA and Clinical Medical College of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Shan","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fuzhou General Hospital of Nanjing Command, PLA and Clinical Medical College of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fuzhou General Hospital of Nanjing Command, PLA and Clinical Medical College of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"bibr1-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219815.83681.f7"},{"key":"bibr2-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011613"},{"key":"bibr3-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1159\/000068481"},{"key":"bibr4-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1159\/000126914"},{"key":"bibr5-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8"},{"key":"bibr6-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.15.1774"},{"key":"bibr7-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.01.007"},{"key":"bibr8-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60109-3"},{"key":"bibr9-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01154.x"},{"key":"bibr10-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.10.012"},{"key":"bibr11-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00169-1"},{"key":"bibr12-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2010.12.004"},{"key":"bibr13-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054025"},{"key":"bibr14-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1856"},{"key":"bibr15-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.1.21"},{"key":"bibr16-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.01.017"},{"issue":"4","key":"bibr17-0891988716673466","first-page":"CD004514","author":"Malouf R","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr18-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001886"},{"key":"bibr19-0891988716673466","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.076349"},{"key":"bibr20-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr21-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(89)90021-6"},{"key":"bibr22-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"bibr23-0891988716673466","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9166-3"},{"key":"bibr24-0891988716673466","unstructured":"Higgins J GS. 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