{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:19:37Z","timestamp":1789370377672,"version":"build-2803163510"},"reference-count":53,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"Foundation for Physical Therapy through the Magistro Family Foundation Research Grant","doi-asserted-by":"publisher","award":["P30 AG035982"],"award-info":[{"award-number":["P30 AG035982"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>The apolipoprotein (APOE) \u03b54 allele, a well-described genetic risk factor for late-onset Alzheimer disease (AD), is associated with sleep disturbances even in cognitively normal older adults, although it is not clear whether this association is independent of sleep apnea. We sought to extend previous studies by examining whether cognitively normal older adults without self-reported sleep apnea who carry the APOE \u03b54 allele have altered sleep characteristics compared to noncarriers. Data from N = 36 (APOE \u03b54 carriers [n = 9], noncarriers [n = 27]) cognitively normal older adults (Clinical Dementia Rating [CDR] scale = 0) without self-reported sleep apnea were used for these analyses. Participants wore an actigraph for 7 days to determine sleep characteristics. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to assess sleep quality and daytime sleepiness, respectively. The APOE \u03b54 carriers had a higher number of awakenings compared to the noncarriers ( P = .02). There was no significant difference in the PSQI global score and the ESS; however, the PSQI subcomponent of daily disturbances was significantly higher in APOE \u03b54 carriers ( P = .03), indicating increased daytime dysfunction is related to disrupted sleep. This study provides evidence that individuals who are cognitively normal and genetically at risk of AD may have disrupted sleep. These findings are consistent with prior studies and suggest that sleep disruption may be present in the presymptomatic stages of AD.<\/jats:p>","DOI":"10.1177\/0891988717720301","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T06:13:56Z","timestamp":1501136036000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Relationship Between Apolipoprotein \u03b54 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults"],"prefix":"10.1177","volume":"30","author":[{"given":"Melike","family":"Kahya","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vidoni","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley N.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine F.","family":"Siengsukon","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"bibr1-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.269"},{"key":"bibr2-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.2334"},{"key":"bibr3-0891988717720301","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113109990134"},{"key":"bibr4-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.04.015"},{"key":"bibr5-0891988717720301","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2802"},{"key":"bibr6-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"bibr7-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340056033"},{"key":"bibr8-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274903"},{"key":"bibr9-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"issue":"5","key":"bibr10-0891988717720301","first-page":"629","volume":"23","author":"Asada T","year":"2000","journal-title":"Sleep"},{"issue":"10","key":"bibr11-0891988717720301","first-page":"693","volume":"18","author":"Cacabelos R","year":"1996","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"bibr12-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1177\/0891988703261994"},{"key":"bibr13-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2016.04.006"},{"key":"bibr14-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003255"},{"key":"bibr15-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"issue":"3","key":"bibr16-0891988717720301","first-page":"111","volume":"42","author":"Graves RS","year":"2015","journal-title":"J Registry Manag"},{"key":"bibr17-0891988717720301","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"bibr18-0891988717720301","volume-title":"Norwegian Manual","author":"Wechsler D.","year":"2007"},{"key":"bibr19-0891988717720301","volume-title":"The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation","volume":"4","author":"Reitan RM","year":"1985"},{"key":"bibr20-0891988717720301","doi-asserted-by":"crossref","unstructured":"Wechsler D. 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