{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:30:38Z","timestamp":1777851038758,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antipsychotics are commonly used for managing behavioral and psychological symptoms of dementia among elderly patients with dementia receiving antidementia drugs (ADDs). However, the use of antipsychotics among these patients has not been investigated since 3 ADDs were approved in 2011 in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We conducted a descriptive study using pharmacy prescription data and identified patients aged \u226565 years who were newly prescribed donepezil, memantine, rivastigmine, and galantamine between January 1, 2012, and September 30, 2014. We determined the proportion of antipsychotic prescription and the factors affecting antipsychotic prescription using multivariable Cox proportional hazard models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>Of 13 876 patients, 1705 were memantine users, and the proportion of antipsychotic prescription among them was the highest (11.1%). Adjusted hazard ratios for donepezil, rivastigmine, and galantamine were 0.66, 0.56, and 0.66, respectively, relative to that for memantine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared to other ADD users, new memantine users were most likely to be prescribed antipsychotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0891988718785775","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T07:40:40Z","timestamp":1531899640000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prescription of Antidementia Drugs and Antipsychotics for Elderly Patients in Japan: A Descriptive Study Using Pharmacy Prescription Data"],"prefix":"10.1177","volume":"31","author":[{"given":"Takahisa","family":"Tsukada","sequence":"first","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan"},{"name":"The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Jyoto Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Doi","sequence":"additional","affiliation":[{"name":"Ain Holdings Inc, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Arai","sequence":"additional","affiliation":[{"name":"Kraft Inc, Chiyoda, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Fujii","sequence":"additional","affiliation":[{"name":"Ain Holdings Inc, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Kraft Inc, Chiyoda, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-4071","authenticated-orcid":false,"given":"Koji","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"bibr1-0891988718785775","unstructured":"World Health Organization. Dementia. World Health Organization. http:\/\/www.who.int\/mediacentre\/factsheets\/fs362\/en\/. Published December 12, 2017. Accessed July 9, 2018."},{"key":"bibr2-0891988718785775","unstructured":"Asada T. The prevalence of dementia and the measures to functional disabilities in the urban areas. The Ministry Health, Labour and Welfare Grant System. 2013. https:\/\/mhlw-grants.niph.go.jp\/niph\/search\/NIDD00.do?resrchNum=201218011A [In Japanese]. Published July 24, 2013. Accessed July 9, 2018."},{"key":"bibr3-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2012.00415.x"},{"key":"bibr4-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1858"},{"key":"bibr5-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu143"},{"key":"bibr6-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1159\/000336710"},{"key":"bibr7-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4483"},{"issue":"11","key":"bibr8-0891988718785775","first-page":"1269","volume":"167","author":"Wooltorton E","year":"2002","journal-title":"CMAJ"},{"key":"bibr9-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040539"},{"key":"bibr10-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.15.1934"},{"key":"bibr11-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052827"},{"key":"bibr12-0891988718785775","unstructured":"The US Food and Drug Administration. The US Food and Drug Administration Public Health Advisory: deaths with antipsychotics in elderly patients with behavioral disturbances. http:\/\/psychrights.org\/drugs\/FDAantipsychotics4elderlywarning.htm. Published April 11, 2005. Accessed July 9, 2018."},{"key":"bibr13-0891988718785775","volume-title":"FDA News: FDA Requests Boxed Warnings on Older Class of Antipsychotic Drugs [News Release]","volume":"16","author":"The US Food and Drug Administration","year":"2008"},{"key":"bibr14-0891988718785775","unstructured":"The Federation of Pharmaceutical Manufacturers\u2019 Associations of Japan. Drug Safety Update No. 141. 2005. https:\/\/www.pmda.go.jp\/files\/000143661.pdf#page=8. [In Japanese]. Published August, 2005. Accessed July 9, 2018."},{"key":"bibr15-0891988718785775","unstructured":"The Federation of Pharmaceutical Manufacturers\u2019 Associations of Japan. Drug Safety Update No.176. 2009. https:\/\/www.pmda.go.jp\/files\/000145507.pdf#page=6. [In Japanese]. Accessed September 30, 2016."},{"key":"bibr16-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.006"},{"key":"bibr17-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4187"},{"issue":"4","key":"bibr18-0891988718785775","first-page":"719","volume":"3","author":"Campbell N","year":"2008","journal-title":"Clin Interv Aging"},{"key":"bibr19-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1949"},{"key":"bibr20-0891988718785775","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0302"},{"key":"bibr21-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002080"},{"key":"bibr22-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1177\/070674371305800404"},{"key":"bibr23-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-016-0057-1"},{"key":"bibr24-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028483"},{"key":"bibr25-0891988718785775","unstructured":"The Ministry of Health, Labour and Welfare. Information about generic drugs and National Health Insurance Drug List. https:\/\/mhlw.go.jp\/topics\/2018\/04\/tp20180401-01.html. [In Japanese]. Updated July 2, 2018. Accessed July 9, 2018."},{"key":"bibr26-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1159\/000084552"},{"key":"bibr27-0891988718785775","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4616-7"},{"issue":"1","key":"bibr28-0891988718785775","first-page":"e00014","volume":"1","author":"Urushihara H","year":"2014","journal-title":"Sci Postscr"}],"container-title":["Journal of Geriatric Psychiatry and Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988718785775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0891988718785775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0891988718785775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:15:40Z","timestamp":1777500940000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0891988718785775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/0891988718785775"],"URL":"https:\/\/doi.org\/10.1177\/0891988718785775","relation":{},"ISSN":["0891-9887","1552-5708"],"issn-type":[{"value":"0891-9887","type":"print"},{"value":"1552-5708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}