{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:42:48Z","timestamp":1790113368982,"version":"4.0.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the validity of health-related quality of life (Hr-QoL) measures in patients with late-stage Parkinson\u2019s disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from patients with late-stage PD and their carers who were assessed with a range of clinical measures and the EQ-5D-3\u00a0L. The DEMQOL-Proxy was completed for 157 patients with a diagnosis of dementia and the PDQ-8 by 401 patients without dementia. Convergent validity was assessed using correlations with measures of Parkinson\u2019s severity, independence and cognitive function, and construct validity using correlations with patients\u2019 own EQ-5D-3\u00a0L scores. In addition, we assessed divergent validity using correlations with carers\u2019 own EQ-5D index, EQ-VAS and Zarit caregiver burden scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients without dementia, both the PDQ-8 and EQ-5D-3\u00a0L correlated with measures of disease severity, dependence and carer burden scores, and PDQ-8 scores moderately with EQ-5D-3\u00a0L and EQ-5D-3\u00a0L VAS scores. In patients with dementia, EQ-5D-3\u00a0L scores correlated with disease severity, cognition and dependence scores, but DEMQOL-Proxy scores were moderately associated only with patients\u2019 dependence and carers\u2019 own EQ-5D-3\u00a0L scores but not patients\u2019 disease severity, EQ-5D-3\u00a0L or cognitive scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PDQ-8 and EQ-5D-3\u00a0L have adequate validity in late stage PD without dementia, but in those with PD and dementia the EQ-5D-3\u00a0L may be preferable to the DEMQOL-Proxy.<\/jats:p>\n                  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