{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:31:45Z","timestamp":1777851105867,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22dk0207053"],"award-info":[{"award-number":["JP22dk0207053"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Suntory Holdings Limited"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer\u2019s disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 9296 community-dwelling subjects aged \u226565\u00a0years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels ( P for trend = .003, P for trend&lt;.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values &lt;.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887231195235","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T01:49:23Z","timestamp":1691113763000},"page":"61-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons"],"prefix":"10.1177","volume":"37","author":[{"given":"Ayumi","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3096","authenticated-orcid":false,"given":"Jun-ichi","family":"Iga","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Tatewaki","sequence":"additional","affiliation":[{"name":"Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Thyreau","sequence":"additional","affiliation":[{"name":"Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Zaidan Niihama Hospital, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Heisei Hospital, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Nakaji","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nakashima","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Matsue Medical Center, Shimane, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-ichi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the JPSC-AD study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"bibr1-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1148\/rg.274065722"},{"issue":"5","key":"bibr2-08919887231195235","first-page":"929","volume":"10","author":"Heier LA","year":"1989","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr3-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"bibr4-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-021-02718-7"},{"key":"bibr5-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8739"},{"key":"bibr6-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx003"},{"key":"bibr7-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011046"},{"key":"bibr8-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011537"},{"key":"bibr9-08919887231195235","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190527"},{"key":"bibr10-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"bibr12-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf077"},{"key":"bibr13-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028229"},{"key":"bibr14-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6598-z"},{"key":"bibr15-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.591586"},{"key":"bibr16-08919887231195235","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3498"},{"key":"bibr17-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-020-00903-3"},{"key":"bibr18-08919887231195235","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215153"},{"key":"bibr19-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac093"},{"key":"bibr20-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25899"},{"key":"bibr21-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21049"},{"key":"bibr22-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2017.11.004"},{"key":"bibr23-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101639"},{"key":"bibr24-08919887231195235","first-page":"3342","volume":"2016","author":"Yushkevich PA","year":"2016","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"bibr25-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"key":"bibr26-08919887231195235","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00406"},{"key":"bibr27-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"bibr28-08919887231195235","volume-title":"Physiology, Pulse Pressure","author":"Homan TD","year":"2022"},{"key":"bibr29-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr30-08919887231195235","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"bibr31-08919887231195235","doi-asserted-by":"publisher","DOI":"10.5551\/jat.GL2017"},{"key":"bibr32-08919887231195235","first-page":"1","volume":"94","author":"Kanazawa M","year":"2005","journal-title":"World Rev Nutr Diet"},{"key":"bibr33-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-0948-3"},{"key":"bibr34-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.344"},{"key":"bibr35-08919887231195235","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"bibr36-08919887231195235","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987","edition":"3"},{"key":"bibr37-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321913"},{"key":"bibr38-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.163055"},{"key":"bibr39-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1159\/000486308"},{"key":"bibr40-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"bibr41-08919887231195235","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy083"}],"container-title":["Journal of Geriatric Psychiatry and Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08919887231195235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08919887231195235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08919887231195235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:16:47Z","timestamp":1777501007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08919887231195235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/08919887231195235"],"URL":"https:\/\/doi.org\/10.1177\/08919887231195235","relation":{},"ISSN":["0891-9887","1552-5708"],"issn-type":[{"value":"0891-9887","type":"print"},{"value":"1552-5708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,3]]}}}