{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:38:12Z","timestamp":1784306292507,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK109950"],"award-info":[{"award-number":["R01DK109950"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX002161-03"],"award-info":[{"award-number":["I01CX002161-03"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Houston Center for Innovations in Quality, Effectiveness and Safety","award":["CIN13-413"],"award-info":[{"award-number":["CIN13-413"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To test the hypothesis that depressive symptoms vary with high-sensitivity C-reactive protein (hs-CRP), among older adults with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross-sectional, secondary analysis of baseline data from two related lifestyle intervention trials. The study sample comprises 148 consecutively recruited, community-dwelling older adults (age &gt;=65\u00a0years) without severe psychiatric illness and with body mass index &gt;=30\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Logarithmically transformed GDS was analyzed as the dependent variable. Independent variables included log-transformed hs-CRP and covariates: sex, age, and concurrent use of antidepressant medication at baseline. An additional analysis was performed using binary conversion of the GDS scores, wherein a cutoff score of 5 was considered positive for depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sample mean GDS score was 2.7 (SD 3.0, range 0 \u2013 14). A significant multivariate model of GDS scores (R\n                      <jats:sup>2<\/jats:sup>\n                      = .089, F = 3.5, P = .010) revealed log-transformed hs-CRP ( P = .017) and male sex ( P = .012) as associated with depressive symptoms. Supplemental analysis demonstrated associations between depressive symptoms and log-transformed hs-CRP (OR 2.17, P = .001) and between depressive symptoms and male sex (OR 3.78, P = .013). Univariate logistic regression found hs-CRP to be associated with depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In older adults with obese BMI, male sex and higher hs-CRP are associated with depression, even in a group with relatively minimal depressive symptoms. Hs-CRP may offer clinical utility as a biomarker for depression among older adults with obese BMI, even among those with non-severe psychiatric symptomatology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887231215041","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T06:56:22Z","timestamp":1699685782000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-2625","authenticated-orcid":false,"given":"Henry D.","family":"Heisey","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States"},{"name":"VA South Central Mental Illness Research, Education, and Clinical Center, Houston, TX, United States"},{"name":"Center for Innovations in Quality, Effectiveness and Safety, Michael E. 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DeBakey Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases, Houston, TX, United States"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Liza Duremdes","family":"Nava","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases, Houston, TX, United States"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Gatchel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States"},{"name":"Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, United States"},{"name":"Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States"},{"name":"Harvard Medical School, McLean Hospital, Belmont, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Kunik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States"},{"name":"VA South Central Mental Illness Research, Education, and Clinical Center, Houston, TX, United States"},{"name":"Center for Innovations in Quality, Effectiveness and Safety, Michael E. 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