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Blood NfL also inversely correlates with cognitive performance in those conditions. However, few studies have assessed NfL as a biomarker of global cognition in individuals demonstrating mild cognitive deficits who are at risk for vascular-related cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the relationship between blood NfL and global cognition in individuals with possible vascular MCI (vMCI) throughout cardiac rehabilitation (CR). Additionally, NfL levels were compared to age\/sex-matched cognitively unimpaired (CU) controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Participants with coronary artery disease (vMCI or CU) were recruited at entry to a 24-week CR program. Global cognition was measured using the Montreal Cognitive Assessment (MoCA) and plasma NfL level (pg\/ml) was quantified using a highly sensitive enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher plasma NfL was correlated with worse MoCA scores at baseline (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      = \u2212.352,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .029) in 43 individuals with vMCI after adjusting for age, sex, and education. An increase in NfL was associated with worse global cognition (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      [SE] = \u22124.81[2.06],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .023) over time, however baseline NfL did not predict a decline in global cognition. NfL levels did not differ between the vMCI (n = 39) and CU (n = 39) groups (\n                      <jats:italic toggle=\"yes\">F<\/jats:italic>\n                      (1, 76) = 1.37,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .245).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma NfL correlates with global cognition at baseline in individuals with vMCI, and is associated with decline in global cognition during CR. Our findings increase understanding of NfL and neurobiological mechanisms associated with cognitive decline in vMCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887241254469","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:05:53Z","timestamp":1715918753000},"page":"62-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-8274","authenticated-orcid":false,"given":"Amish","family":"Gaur","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute"},{"name":"University of 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