{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:32:00Z","timestamp":1785450720070,"version":"3.56.0"},"reference-count":78,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS099129"],"award-info":[{"award-number":["R01NS099129"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in older adults but has not been explored specifically for Parkinson disease dementia (PDD). We used adjusted Cox models to estimate the risk of incident PDD associated with demographic factors, clinical characteristics, and time-varying total ACB in a longitudinal, deeply-phenotyped prospective PD cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major findings<\/jats:title>\n                    <jats:p>56.5% of study participants were taking ACB-scale drugs at enrollment. Increasing age, motor symptom burden and psychosis were associated with PDD risk. Female sex and educational achievement were protective against PDD. ACB categories were not associated with PDD overall, but depression and impulse control disorder were strongly associated with PDD in a subsample with high baseline ACB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient and clinical factors modify PDD risk. PD drug safety and drug-disease interaction studies may require considering multiple mechanisms and including dose-based, prospectively acquired medication exposure measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08919887241313376","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:46:20Z","timestamp":1736246780000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-764X","authenticated-orcid":false,"given":"Thanh Phuong","family":"Pham Nguyen","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Thibault","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly L.","family":"Gray","sequence":"additional","affiliation":[{"name":"University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center"},{"name":"University of Pennsylvania Perelman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison W.","family":"Willis","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"University of Pennsylvania Perelman School of Medicine"},{"name":"Corporal Michael J. Crescenz VA Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.034"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.27"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.229"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.7663"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0156-4"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1315"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0677"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e7f2ab"},{"issue":"3","key":"e_1_3_6_10_2","first-page":"471","article-title":"Midlife anticholinergic drug use, risk of Alzheimer's disease, and brain atrophy in community-dwelling older adults","volume":"3","author":"Chuang YF","year":"2017","unstructured":"Chuang YF, Elango P, Gonzalez CE, Thambisetty M. Midlife anticholinergic drug use, risk of Alzheimer's disease, and brain atrophy in community-dwelling older adults. Alzheimers Dement. 2017;3(3):471-479.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.05.014"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa033"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13347"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212769"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00886877"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.06.022"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2305"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.186239"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28115"},{"key":"e_1_3_6_20_2","unstructured":"Fahn S Marsden CD Calne DB Goldstein M. Recent developments in Parkinson\u2019s disease. 1987 Vol. 2 (pp.153-163 293-304). Florham Park NJ: Macmillan Health Care Information."},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21415"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1300\/J018v05n01_09"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13647"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2021.1999505"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317511412046"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13660"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22441"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22173"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988712445086"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/09084282.2012.670168"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29410"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2005.00340.x"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.02.12"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050005"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191683"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004764"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S203690"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870050212"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1596"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-016-0058-0"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12962"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.9.809"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.4\/cepperson"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1661"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2020.100654"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642014DN82000006"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318211c83c"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02615-x"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10219"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2018.21"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.024"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.083113"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068010.82167.CF"},{"key":"e_1_3_6_58_2","first-page":"3256542","article-title":"Management of psychosis in Parkinson\u2019s disease: emphasizing clinical subtypes and pathophysiological mechanisms of the condition","volume":"2017","author":"Taddei RN","year":"2017","unstructured":"Taddei RN, Cankaya S, Dhaliwal S, Chaudhuri KR. Management of psychosis in Parkinson\u2019s disease: emphasizing clinical subtypes and pathophysiological mechanisms of the condition. Parkinsons Dis. 2017;2017:3256542.","journal-title":"Parkinsons Dis"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20965"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-013-0281-2"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.166"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0004"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.90"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.60"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061791"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000583"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12601"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10736-x"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.10.004"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18040465"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.02.018"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26160"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105134"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2021.03.002"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.198"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01309"},{"key":"e_1_3_6_77_2","first-page":"225","article-title":"The cognitive impact of anticholinergics: a clinical review","volume":"4","author":"Campbell N","year":"2009","unstructured":"Campbell N, Boustani M, Limbil T, et al. The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging. 2009;4:225-233.","journal-title":"Clin Interv Aging"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0580"},{"key":"e_1_3_6_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4507"}],"container-title":["Journal of Geriatric Psychiatry and Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08919887241313376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08919887241313376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08919887241313376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:17:01Z","timestamp":1777501021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08919887241313376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/08919887241313376"],"URL":"https:\/\/doi.org\/10.1177\/08919887241313376","relation":{},"ISSN":["0891-9887","1552-5708"],"issn-type":[{"value":"0891-9887","type":"print"},{"value":"1552-5708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}