{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:01:31Z","timestamp":1790650891829,"version":"4.1.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"MVP Study","award":["NIH K01-ATT004404"],"award-info":[{"award-number":["NIH K01-ATT004404"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Geriatr Psychiatry Neurol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Physical activity has been shown to improve motor symptoms in numerous Parkinson\u2019s Disease (PD) clinical trials. However, the relationship between physical activity (PA), patient-reported outcomes, and quality of life (QoL) in a community-dwelling cohort has not been well-characterized.\n                    <jats:bold>Methods:<\/jats:bold>\n                    To evaluate this association, data were obtained from the internet-based Modifiable Variables in Parkinsonism Study (n = 415). Patient-reported outcomes and QoL were assessed by the Patient-Reported Outcomes in Parkinson\u2019s Disease (PRO-PD) and Patient-Reported Outcomes Measurement Information System (PROMIS), respectively. Regression models controlled for age, sex, and disease duration.\n                    <jats:bold>Results:<\/jats:bold>\n                    As PA increased, PROMIS scores increased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) and motor and non-motor symptom PRO-PD scores decreased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) implying improved symptoms and QoL. The association between PA and symptom severity was significant in women, but not men.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These data may imply improved symptoms and QoL with increased PA frequency in individuals with PD. Sex differences in the relationship between PA and PD outcomes warrant further investigation.\n                  <\/jats:p>","DOI":"10.1177\/08919887251346495","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:06:03Z","timestamp":1748595963000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Physical Activity, Patient-Reported Outcomes, and Quality of Life in Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-9128","authenticated-orcid":false,"given":"James F.","family":"Morley","sequence":"first","affiliation":[{"name":"Crescenz VA Medical Center"},{"name":"University of Pennsylvania Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Subramanian","sequence":"additional","affiliation":[{"name":"West LA VA Medical Center"},{"name":"UCLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Farahnik","sequence":"additional","affiliation":[{"name":"Bastyr University"},{"name":"University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-7314","authenticated-orcid":false,"given":"Leah","family":"Grout","sequence":"additional","affiliation":[{"name":"Southern California University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristal","family":"Salcido","sequence":"additional","affiliation":[{"name":"Bastyr University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josi","family":"Kurtzer","sequence":"additional","affiliation":[{"name":"Bastyr University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie K.","family":"Mischley","sequence":"additional","affiliation":[{"name":"Bastyr University"},{"name":"University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101834"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00218-x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1498756"},{"key":"e_1_3_4_5_2","unstructured":"World Health Organization. Parkinson disease. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease. Updated 9 August 2023. Accessed 27 March 2024."},{"key":"e_1_3_4_6_2","volume-title":"Parkinson\u2019s disease: causes, symptoms, and treatments","author":"National Institute on Aging","unstructured":"National Institute on Aging. Parkinson\u2019s disease: causes, symptoms, and treatments. National Institutes of Health (NIH). https:\/\/www.nia.nih.gov\/health\/parkinsons-disease\/parkinsons-disease-causes-symptoms-and-treatments. Updated 14 April 2022. 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